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Brain pressure breakthrough? drug cocktail shows promise in surgery

NCT ID NCT07064720

Disease control Sponsor: Cairo University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether adding dexmedetomidine to the standard drug mannitol can better control brain pressure during robotic prostate surgery. Sixty adults participated. The main goal was to measure changes in the optic nerve sheath, a marker of brain pressure. The study is complete, but results are not yet published.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
dexmedetomidine added to mannitol
What this could lead to
If it works, this could offer a better way to control dangerous brain pressure during surgery, potentially reducing complications.
What could go wrong
This is a small, early-phase trial (60 people) in a specific surgery type. Results may not apply to other situations, and the drug combination could cause side effects like low blood pressure or slow heart rate.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2/3

Runs two stages together: whether the treatment works, then large-scale confirmation.

Participants

60 people

The number who actually took part.

Started

Jul 2024

Finished

Jan 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

40 to 70 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: ASA I-II Patients scheduled for elective robot-assisted laparoscopic prostatectomy Exclusion Criteria: * • ASA physical status \> II * Cardiac patients * Cerebrovascular disease * Glaucoma * Hepatic failure * Renal failure * History of anaphylactic reaction to dexmedetomidine or mannitol * Hemodynamic instability * Cannot measure ONSD for example due to ophthalmological problems. * Any cause of preoperative increase in ICP for example intracranial space occupying lesions.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Dexmedetomidine

Contacts and locations

Locations

  • facility of medicine Cairo university

    Cairo, 12613, Egypt

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