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New painkiller combo could make knee surgery recovery easier

NCT ID NCT07131579

Symptom relief Sponsor: Mansoura University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only This study
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether adding dexmedetomidine to spinal anesthesia can extend pain relief after knee surgery. One hundred adults scheduled for elective knee surgery will receive either the drug or a placebo. Researchers will measure how long it takes before patients need additional pain medication.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Dexmedetomidine
What this could lead to
If it works, this could offer a way to reduce pain after knee surgery without strong side effects like breathing problems.
What could go wrong
This is a small, early-stage study. The drug may not provide meaningful extra pain relief, and it could cause sedation or low blood pressure.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 100 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jan 2026

Expected to finish

Aug 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 60 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age 18-60 years * American Society of Anesthesiologists (ASA) Physical Status Classification System I or II * Scheduled for elective knee surgery under spinal anesthesia * Body mass index (BMI) 18-30 kg/m² * Able to provide informed consent Exclusion Criteria: * Pregnant or lactating women * Hypersensitivity to dexmedetomidine * Chronic kidney diseases serum creatinine \>1.5 mg\\dl or Patient has known renal disease * Chronic opioid or sedative use * Any cardiac conduction abnormalities * Uncontrolled arterial hypertension * Neuropathy * Diabetes mellitus * Impaired perfusion of the operative limb (Edema, Peripheral vascular Disease e.g "Raynaud Phenomenon") * History or recent lower limb deep venous thrombosis (DVT) or Phlebitis * Infection or vascular access limitation in the operated lower limbs * Any contraindication of spinal anesthesia e.g "Coagulopathy" * Any contraindications for tourniquet e.g "sickle cell anemia"

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Dexmedetomidine analgesia Knee surgery

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    The full official record for this study. This one lists no contact details, but it is the first place any would appear.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Faculty of Medicine-Mansoura University

    Al Mansurah, Egypt

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