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Study tests drug to prevent blood pressure spikes during surgery in hypertensive patients

NCT ID NCT07557680

Symptom relief Sponsor: Sindh Institute of Urology and Transplantation Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at whether giving a sedative called dexmedetomidine before placing a breathing tube can prevent sudden rises in blood pressure and heart rate in patients with controlled high blood pressure. 70 adults having planned surgery under general anesthesia took part. The goal was to see if the drug makes the procedure safer by reducing stress on the heart.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 3

Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.

Participants

70 people

The number who actually took part.

Started

Jan 2025

Finished

Jun 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 65 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Ages from 18 to 65 years. * Patients with a known case of controlled hypertension. * ASA II * Elective surgical procedure under general anaesthesia. * Mallampati grades 1 and 2. * Patients consenting to participate in this study Exclusion Criteria: * Patients with an anticipated difficult intubation. * Those requiring more than 15 seconds or more than one attempt or use of a bougie during laryngoscopy. * A patient who has not taken an antihypertensive drug early morning on the day of surgery. * Patients with a history of allergy to drugs being used. * Patients with uncontrolled hypertension (BP \> 140/90 mmHg). * History of bradycardia (resting heart rate \< 60 bpm). * Patients on beta blockers if resting heart rate \< 60 bpm. * History of valvular heart disease, uncontrolled diabetes, liver, or kidney disease. * Pregnancy.

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Conditions

The condition(s) this trial relates to.

Fractures, Stress hypertensive disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Anesthesia Hemodynamic response Hypertension

Contacts and locations

Locations

  • Sindh Institute of Urology and Transplantation

    Karachi, Sindh, 74200, Pakistan

More trials for these conditions

Other studies related to the condition(s) this trial covers.