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Can kitchen spices soothe gulf war illness? new trial seeks answers

NCT ID NCT05377242

Symptom relief Sponsor: University of Alabama at Birmingham Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 30, 2026 · Updated 3 times

Summary

This study tests whether three natural supplements—curcumin (from turmeric), resveratrol (from grapes), and stinging nettle—can improve physical and mental health in veterans with Gulf War Illness. 390 veterans from across the U.S. take part from home, reporting their symptoms online. The goal is to find a simple, low-cost way to ease this chronic condition.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
curcumin, resveratrol, and stinging nettle (dietary supplements)
What this could lead to
If effective, these supplements could offer a safe, accessible way to ease physical and mental symptoms of Gulf War Illness.
What could go wrong
This is an early-stage trial with no placebo control, so results may be inconclusive. Supplements are not FDA-approved drugs, and benefits may be small or absent.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

390 people

The number who actually took part.

Started

May 2023

Finished

Jun 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

45 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

In accordance with the Institute of Medicine (IOM) 2014 guidance, participants must meet both the Kansas and CDC (Centers for Disease Control and Prevention) Case Definitions of GWI. Participants must have been deployed to the Persian Gulf Region during the 1990-1991 Gulf War, meet symptom domain criteria, and not have exclusionary medical conditions. The case definitions will be used for inclusionary screening purposes. Inclusion Criteria: * Meets Kansas GWI Case Definition * Meets CDC GWI Case Definition * Able to commit to a 10-month study Exclusion Criteria: * Currently involved in an experimental treatment study * Abnormal liver function values * Abnormal kidney function values * Currently pregnant * Blood clotting disorder (contraindicated with all three botanicals) * Reported diagnosis of diabetes with an A1C greater than 9 * The use of contraindicated medications (see below): * Anticoagulant medications (such as warfarin, heparin, etc.) * Lithium * Tacrolimus (Prograf) * Cancer medications (Alkylating agents, antitumor antibiotics, Topoisomerase I inhibitors, Tamoxifen)

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Conditions

The condition(s) this trial relates to.

persian gulf syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Gulf war illness

Contacts and locations

Locations

  • The University of Alabama at Birmingham

    Birmingham, Alabama, 35233, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.