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New study tests which braces wire hurts less and works better

NCT ID NCT06653881

Knowledge-focused Sponsor: Postgraduate Institute of Dental Sciences Rohtak Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study compared two types of archwires used in braces: conventional nickel-titanium and copper-nickel-titanium. The goal was to see which wire straightens teeth more efficiently and causes less pain, measured using a pain scale and a biomarker called prostaglandin E2. Thirty people aged 18 to 25 with moderate crowding took part. The results may help orthodontists choose the best wire for a more comfortable treatment.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
archwires (conventional nickel-titanium and copper-nickel-titanium)
What this could lead to
If successful, this could help orthodontists choose which archwire causes less pain and aligns teeth faster, improving patient comfort.
What could go wrong
This is a small, completed study with only 30 participants. Results may not apply to all patients or types of crowding.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

30 people

The number who actually took part.

Started

Jun 2024

Finished

Sep 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 25 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Orthodontic patients to be treated with fixed orthodontic treatment requiring non-extraction treatment plan. * Patients' with pre-treatment moderate crowding between 4-6mm in the mandibular anterior region assessed with Little's Irregularity index. * Male and female patients between 18 and 25 years of age with full complement of teeth erupted to the occlusal level (excluding third molars). * Non syndromic patients and no impaction of teeth except third molars. * No history of previous orthodontic treatment. * Optimal periodontal condition and good oral hygiene. Exclusion Criteria: * Acute or chronic medical patients that are under medications and would affect tooth movement. * Medical conditions that contraindicate orthodontic treatment. * Craniofacial anomalies and syndromes, congenitally missing teeth (excluding third molars) or severe facial asymmetries. * Any systemic disease affecting bone and general growth. * Patients' with known allergy to metal and components used in orthodontic treatment.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Anterior teeth alignment efficiency Pain perception PGE2 biomarker and their correlation

Contacts and locations

Locations

  • PGIDS

    Rohtak, Haryana, 124001, India

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