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Ice before the needle: simple trick to beat root canal pain?

NCT ID NCT07517367

Symptom relief Sponsor: Ondokuz Mayıs University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether placing an ice pack on the gum for 5 minutes before a numbing injection can improve pain control during root canal treatment. It involves 98 adults with severe, irreversible tooth nerve pain. The goal is to see if this simple cold therapy reduces the need for extra numbing shots and makes the procedure more comfortable.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
intraoral cryotherapy (ice packs applied to the gum)
What this could lead to
If it works, this could offer a simple, drug-free way to make dental numbing more effective for people with severe tooth pain.
What could go wrong
This is a small, early-phase trial. The benefit may be small or not apply to all patients. Ice packs can cause temporary discomfort or cold sensitivity.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 4

Runs after approval, following long-term safety and how well the treatment works in everyday use.

Participants

About 98 people

The number the study aims to enrol. It can still change while the study runs.

Started

Dec 2025

Expected to finish

Aug 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 60 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adults aged 18 to 60 years * Classified as ASA Physical Status I or II * Presence of symptomatic irreversible pulpitis in a single-rooted mandibular incisor tooth * Preoperative pain score ≥8 on the Numerical Rating Scale (NRS) and Wong-Baker FACES scale * Positive response to cold test and electric pulp testing * Absence of periapical pathology on preoperative periapical radiograph * No analgesic intake within 6 hours prior to treatment * Ability to understand and complete pain assessment scales * Willingness to provide written informed consent Exclusion Criteria: * Age below 18 years or above 60 years * Pregnancy * Known allergy to local anesthetic agents * Diagnosis of diabetes mellitus * Presence of hypothyroidism * Diagnosis of adrenal insufficiency * Presence of Raynaud disease * Uncontrolled diabetes (HbA1c \>7%) * Presence of periapical pathology detected radiographically * Presence of sinus tract * Presence of intraoral or extraoral swelling * Teeth diagnosed with necrotic pulp * Presence of referred pain from another tooth or anatomical structure

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Conditions

The condition(s) this trial relates to.

pulpitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Symptomatic irreversible pulpitis (SIP)

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Ondokuz Mayıs University

    RECRUITING

    Samsun, Atakum, Turkey (Türkiye)

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