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Freezing nerves during lung transplant may cut pain and morphine use

NCT ID NCT06959056

Symptom relief Sponsor: University Hospital, Gasthuisberg Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This pilot study tests a technique called cryo-analgesia, where doctors freeze chest nerves during double lung transplant surgery. The goal is to see if this reduces pain, morphine use, and time in the hospital for people with end-stage COPD. Forty participants will either get the nerve freezing or standard pain treatment, and be followed for one year. It is an early, small study to see if the approach is worth testing in larger trials.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
cryo nerve block (freezing of chest nerves during surgery)
What this could lead to
If it works, this could offer a way to reduce severe chest pain and morphine use after lung transplantation, potentially speeding up recovery.
What could go wrong
This is a very small pilot study with only 40 people, so results may not apply to everyone. The nerve freezing could cause complications or not improve pain enough to change standard care.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 40 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jan 2026

Expected to finish

Dec 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Voluntary written informed consent of the participant or their legally authorized representative has been obtained prior to any screening procedures 2. At least 18 years of age at the time of signing the Informed Consent Form (ICF) 3. Bilateral lung transplantation at UZ Leuven 4. Indication for transplantation: End stage chronic obstructive pulmonary disease (COPD) 5. Storage of lungs on classic ice, cooled system (LUNGguard® (Paragonix) or X°Port Lung Transport Device (Traferox Technologies Inc.) ) are all permitted 6. Patients that have undergone lung volume reduction or talcage are not a contraindication for participation in the study. Exclusion Criteria: 1. Unilateral lung transplantation 2. Lobar transplantation 3. Donor lung reconditioning using ex-vivo lung perfusion (EVLP) 4. Combined organ transplantation 5. Chronic opioid use pre-operatively 6. Participation in an interventional Trial with an investigational medicinal product (IMP) or device (IMD) that could potentially influence the post-operative outcomes of this study

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Conditions

The condition(s) this trial relates to.

chronic obstructive pulmonary disease Pain

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Lung transplant; pain

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • University Hospitals Leuven

    RECRUITING

    Leuven, Vlaams-Brabant, 3000, Belgium

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