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Could a simple saliva test replace blood draws for cortisol screening?

NCT ID NCT07350031

Diagnosis Sponsor: Rigshospitalet, Denmark Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looked at whether a saliva test can accurately measure cortisol levels after a dexamethasone suppression test, compared to the standard blood test. Researchers studied about 100 patients with adrenal incidentalomas (non-cancerous growths on the adrenal gland) and 100 healthy volunteers. If saliva testing proves reliable, it could offer a simpler, less invasive way to screen for excess cortisol production.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
1 mg overnight dexamethasone suppression test (diagnostic test)
What this could lead to
If successful, this could make screening for cortisol excess easier and less invasive by using saliva instead of blood tests.
What could go wrong
This is a completed observational study, not a treatment trial. Saliva testing may not be as accurate as blood testing in all patients, and results may not change current clinical practice.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

209 people

The number who actually took part.

Started

Nov 2016

Finished

Apr 2024

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

The patient group were patients newly diagnosed with an adrenal incidentaloma and referred to either the Department of Nephrology and Endocrinology, Copenhagen University Hospital, Rigshospi-talet, Denmark or Department of Medicine, Copenhagen University Hospital Herlev Gentofte, Herlev, Denmark. The controls were recruited through social media, online participant recruitment platform , the hospital website, and physical posters in public spaces around Copenhagen, Denmark.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria (patients): * age ≥ 18 years, a new diagnosis of an adrenal incidentaloma (defined as an adrenal mass \> 1 cm detected when using diagnostic imaging for non-related reasons). Inclusion Criteria (controls): * age ≥ 18 years, no previous history of conditions involving the adrenal glands Exclusion Criteria (patients): * active cancer; an adrenal incidentaloma suspected of malignancy; bilateral adrenal incidentalomas; pregnancy and breastfeeding; conditions or medical treatments that interfere with dexamethasone metabolism and cortisol metabolism/measurements; severe comorbidities; chronic kidney disease (defined as an estimated glomerular filtration rate \< 60 ml/min); and inability to provide written informed consent. Exclusion Criteria (controls): * active cancer; pregnancy and breastfeeding; conditions or medical treatments that interfere with dexamethasone metabolism and cortisol metabolism/measurements; severe comorbidities; chronic kidney disease (defined as an estimated glomerular filtration rate \< 60 ml/min); and inability to provide written informed consent.

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Conditions

The condition(s) this trial relates to.

adrenal cortex adenoma Adrenal incidentaloma Cushing syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Adrenal incidentaloma Hypercortisolism

More trials for these conditions

Other studies related to the condition(s) this trial covers.