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Could surgery after chemo double survival for advanced stomach cancer?

NCT ID NCT07241715

Disease control Sponsor: National University Hospital, Singapore Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looks at whether surgery to remove stomach cancer that has spread to the abdomen can help people live longer when done after chemotherapy. About 300 adults whose cancer responded well to initial treatment will be randomly assigned to either have surgery plus more therapy or continue therapy alone. The main goal is to see if surgery improves overall survival and quality of life.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Conversion surgery (surgery to remove the stomach tumor and cancer spread) plus systemic therapy (chemotherapy, targeted therapy, immunotherapy) with or without chemotherapy given directly into the abdomen
What this could lead to
If it works, this could show that surgery after chemotherapy helps people with advanced stomach cancer live longer and have a better quality of life.
What could go wrong
This is a mid-stage trial, so results are not yet proven. Surgery in this setting carries risks like infection or complications, and the cancer may still come back.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2/3

Runs two stages together: whether the treatment works, then large-scale confirmation.

Participants

About 300 people

The number the study aims to enrol. It can still change while the study runs.

Started

Feb 2026

Expected to finish

Jan 2034

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

21 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * GCPM detected on surgical exploration and demonstrated by histology or cytology * Primary GC not resected * Age \> 21 (or \> 18 as allowed by individual institution review boards) Exclusion Criteria: * Pregnant and lactating females * Prior surgical treatment for GC involving resection * Clinical or radiological progression during 1st line systemic treatment

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Conditions

The condition(s) this trial relates to.

gastric cancer gastric neoplasm peritoneal carcinomatosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Gastric cancer stage IV Peritoneal metastasis

Contacts and locations

Locations

  • National University Hospital

    Singapore, Singapore

More trials for these conditions

Other studies related to the condition(s) this trial covers.