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Heated chemo during surgery: new hope for advanced pancreatic cancer?

NCT ID NCT07493421

Disease control Sponsor: Unidade Local de Saúde São João Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether a major surgery that removes the pancreatic tumor and all visible cancer in the abdomen, followed by pumping heated chemotherapy drugs directly into the belly, is safe for people with pancreatic cancer that has spread to the lining of the abdomen. Twenty adults whose cancer is stable after at least 6 months of standard chemotherapy will receive this intensive procedure. The main goals are to see if the risk of dying within 90 days is low and to measure side effects and quality of life one year later.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 20 people

The number the study aims to enrol. It can still change while the study runs.

Started

Mar 2026

Expected to finish

Oct 2028

An estimate. End dates often move.

Lead sponsor

A government agency

The lead sponsor is a government body.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Pancreatic adenocarcinoma * Histologically confirmed peritoneal metastasis * Excluded other sites of metastasis (except ovary) * PCI less than or equal to 6 * Age \> 18 years * ECOG performance status 0-1 * Written informed consent Exclusion Criteria: * Pregnancy * Intestinal obstruction * Renal insufficiency (GFR \< 45 ml/min)

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Conditions

The condition(s) this trial relates to.

neoplasm Neoplasm Metastasis pancreatic adenocarcinoma pancreatic ductal adenocarcinoma pancreatic neoplasm peritoneal carcinomatosis peritoneal neoplasm peritoneum cancer

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Pancreatic adenocarcinoma Peritoneal (metastatic) cancer

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    3 sites in 2 countries. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Botton/Chamaplimaud Pancreatic cancer center

    NOT_YET_RECRUITING

    Lisbon, Lisbon District, 1400-038, Portugal

  • ULS São João

    RECRUITING

    Porto, 4200-319, Portugal

  • Zhongshan Hospital, Fudan University

    NOT_YET_RECRUITING

    Shanghai, shangaiShanghai Municipality, 200000, China

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