Which sedative combo is best for stomach scope procedures?
NCT ID NCT07190612
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tested three different drug combinations to sedate patients during upper gastrointestinal endoscopy (a scope procedure to examine the stomach and esophagus). 75 adults were randomly assigned to receive propofol plus either ketamine, dexmedetomidine, or midazolam. Researchers measured how quickly patients woke up and how well they were sedated. The goal is to find the safest and most effective sedation approach for routine endoscopic procedures.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- propofol combined with either ketamine, dexmedetomidine, or midazolam
- What this could lead to
- If successful, this could help doctors choose the best sedation method for upper GI endoscopy, leading to faster recovery and fewer side effects.
- What could go wrong
- This is a small, completed Phase 4 trial with only 75 participants, so results may not apply to all patients. The study compares existing drugs, not a new breakthrough.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Phase 4
Runs after approval, following long-term safety and how well the treatment works in everyday use.
- Participants
-
75 people
The number who actually took part.
- Started
-
Dec 2024
- Finished
-
Apr 2026
- Lead sponsor
-
Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
-
18 to 65 years
- Sex
-
Anyone
- Healthy volunteers
-
Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Both male and female patients aged between 18 and 65 years * Patients who are scheduled for elective upper gastrointestinal endoscopic procedures with sedation * Patients who are classified as ASA (American Society of Anesthesiologists) I and II Exclusion Criteria: * Patient's refusal to participate * Respiratory compromise as patients with respiratory failure or with active chest conditions, e.g., bronchial asthma or pneumonia * Cardiovascular compromise including heart failure and shocked patients * Severe uncontrolled hematemesis with shock or risk of aspiration. * Patients who are allergic or have any contraindications to any of the used drugs. * Patients who have a chronic neuropsychiatric disorder or are on a neuropsychiatric drug. * Patients on long-term sedative medication have a history of drug or alcohol abuse. * Pregnancy and lactation
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for Anesthesia are added.
Genom att skicka in godkänner du våra Användarvillkor
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Faculty of Medicine
Cairo, Egypt
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Can a gentler anesthesia cocktail protect a child's developing brain?
- Which monitor reads a Child's pain best during surgery?
- Propofol vs. inhaled anesthesia: which one spares your recovery?
- Which epidural technique best handles a cesarean emergency?
- Could a sleep drug shield older hearts from post-surgery delirium?
- How do countries train anesthesia residents? a global snapshot