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Laser vs. ultrasound: which zaps Crow's feet best?

NCT ID NCT01529983

Symptom relief Sponsor: Northwestern University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 01, 2026 · Last updated Jul 02, 2026 · Updated 1 time

Summary

This pilot study compares two FDA-approved cosmetic procedures—fractional laser and high-intensity focused ultrasound—for treating wrinkles around the eyes (crow's feet and lower eyelid lines). About 20 adults aged 35–60 with moderate wrinkles will receive one treatment on each side of the face, and doctors will compare results at 1 and 3 months. The goal is to see which method works better and is preferred by patients.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
1550-nm fractional laser and high-intensity focused ultrasound
What this could lead to
If one method proves clearly better, it could become the preferred option for treating crow's feet and lower eyelid wrinkles.
What could go wrong
This is a very small early-phase pilot study with only 20 people, so results may not apply to everyone. Both procedures can cause temporary redness, swelling, or discomfort.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Early phase 1

The earliest testing in people: a first look at safety, in a very small group.

Participants

About 20 people

The number the study aims to enrol. It can still change while the study runs.

Start date

Feb 2012

Finished

May 2024

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

35 to 60 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Age 35-60 years old male and female subjects with moderate lower eyelid rhytids and crowsfeet 2. Subjects with Fitzpatrick skin type I-III. 3. Subjects who are willing, have the ability to understand and provide informed consent, and are able to communicate with the investigator. Exclusion Criteria: 1. Subjects who have received injectable soft-tissue augmentation materials to the face, or facial ablative resurfacing, within the past 6 months. 2. Subjects who were received injectable botulinum toxin to the face, or any nonablative laser treatment to the face, within the past 3 months. 3. Subjects who have local infections, open facial wounds, or other significant local skin disease that would interfere with periorbital treatment with energy devices. 4. Subjects who are allergic to lidocaine or prilocaine. 5. Subjects who have a history of abnormal scarring in the treatment area. 6. Subject who have ectropion or or other eyelid disfigurement. 7. Subjects who have history of isotretinoin use in the preceding year 8. Pregnant or lactating individuals

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Wrinkles

Contacts and locations

Locations

  • Northwestern University Feinberg School of Medicine, Department of Dermatology

    Chicago, Illinois, 60611, United States

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