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Botox vs. xeomin: which smooths wrinkles better?

NCT ID NCT02019004

Symptom relief Sponsor: Northwestern University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 01, 2026 · Last updated Jul 02, 2026 · Updated 1 time

Summary

This study compares two popular wrinkle treatments—Botox and Xeomin—for forehead lines and frown lines between the eyebrows. Twenty healthy adults aged 20 to 65 with moderate wrinkles receive both treatments on different sides of their face, and doctors rate the results over six months. The goal is to see if one works better or lasts longer.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
onabotulinum toxin A (Botox) and incobotulinum toxin A (Xeomin)
What this could lead to
If one works better or lasts longer, it could help people choose the best option for wrinkle treatment.
What could go wrong
This is a very small early-phase study with only 20 people, so results may not apply to everyone. Side effects like bruising or drooping are possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Early phase 1

The earliest testing in people: a first look at safety, in a very small group.

Participants

About 20 people

The number the study aims to enrol. It can still change while the study runs.

Start date

Nov 2013

Expected to finish

Dec 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

20 to 65 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Females and males 2. In good health 3. Is 20-65 years of age 4. Has static and moderate dynamic forehead/glabellar wrinkles 5. Has willingness and the ability to understand and provide informed consent and communicate with the study staff Exclusion Criteria: 1. Pregnant or lactating 2. Younger than 20 or older than 65 years of age 3. Has received the following treatments in the forehead or glabellar region: 1. botulinum toxin injections in the past 6 months 2. ablative laser procedure in the past 6 months 3. radiofrequency device treatment in the past 6 months 4. ultrasound device treatment in the past 6 months 5. medium to deep chemical peel in the past 6 months 6. temporary soft tissue augmentation material in the area to be treated in the past year 7. semi-permanent soft tissue augmentation material in the area to be treated in the past 2 years 8. permanent soft tissue augmentation material in the area to be treated 4. Is planning to receive within the next 6 months, any cosmetic procedure (such as any chemical peels, botulinum toxin injections, ablative or non-ablative laser procedures, filler injections, radiofrequency procedures, dermabrasion, ultrasound and face lifting procedures) in the forehead or glabellar region. 5. Is planning to use tretinoin or retinoic acid in the next 6 months 6. Has an active infection in the forehead or glabellar region (excluding mild acne) 7. Is allergic to cow's milk protein 8. Is allergic to albumin 9. Taking aminoglycoside 10. Is currently using anticoagulation therapy 11. Has a history of bleeding disorders 12. Has a mental illness 13. Unable to understand the protocol or to give informed consent

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Wrinkles

Contacts and locations

Locations

  • Northwestern University Department of Dermatology

    Chicago, Illinois, 60611, United States

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