Simpler stem cell collection could ease donor burden in Life-Threatening anemia

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients with newly diagnosed or relapsed severe aplastic anemia (SAA) or very severe aplastic anemia (vSAA) according to the Camitta criteria. * SAA is defined as bone marrow cellularity \<25% and at least two of the following peripheral blood criteria: absolute neutrophil count \<0.5 × 10\^9/L, platelet count \<20 × 10\^9/L, or reticulocyte count \<20 × 10\^9/L. * vSAA is defined as SAA with an absolute neutrophil count \<0.2 × 10\^9/L. * Age 18 to 40 years. * Availability of a haploidentical related donor. * Eastern Cooperative Oncology Group (ECOG) performance status of 0 to 2. * Adequate organ function, defined as follows: * Cardiac function: left ventricular ejection fraction ≥50% and no severe arrhythmia. * Hepatic function: total bilirubin ≤2 times the upper limit of normal and alanine aminotransferase/aspartate aminotransferase ≤3 times the upper limit of normal. * Renal function: creatinine clearance ≥60 mL/min. * No active infection. * For women of childbearing potential, a negative pregnancy test is required. * All patients must agree to use effective contraception during the study period. * Written informed consent provided by the patient or legal representative. Exclusion Criteria: * Presence of hematologic malignancy or myelodysplastic syndrome-related chromosomal abnormalities, such as +8 or del(7q). * Prior allogeneic hematopoietic stem cell transplantation or prior organ transplantation. * Availability of an HLA-matched sibling donor. * Active uncontrolled infection, including unresolved invasive fungal disease, active tuberculosis, sepsis, or other uncontrolled infections. * Severe comorbidities, defined as a Hematopoietic Cell Transplantation-Comorbidity Index (HCT-CI) score ≥4, or uncontrolled autoimmune disease. * Donor-related contraindications, including donor age \<12 years or \>65 years, donor body mass index \<18 or \>35 kg/m², contraindications to anesthesia, or contraindications to bone marrow harvest. * Psychiatric illness that prevents cooperation with study procedures, or any condition considered by the investigator to make the patient unsuitable for study participation.