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Which drug combo works best for Pain-Free tooth pulls?

NCT ID NCT06867068

Symptom relief Sponsor: Albert Einstein College of Medicine Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This completed pilot study tested two different IV drug combinations used to sedate people during wisdom tooth removal. One combo used ketamine, the other used propofol instead. Researchers measured how quickly patients recovered, whether they remembered the procedure, and how satisfied both patients and surgeons were. The goal was to gather early data to design a larger, more definitive trial.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Midazolam, fentanyl, ketamine, propofol, and nitrous oxide
What this could lead to
If this pilot shows one combo is better, it could lead to a larger trial that helps doctors choose the best sedation for wisdom tooth removal.
What could go wrong
This is a small, early-phase pilot study (73 people) meant only to gather preliminary data. It cannot yet prove which combo is safer or more effective.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 1

The first testing in people. Mainly checks safety and dose, usually in a small group.

Participants

73 people

The number who actually took part.

Started

Oct 2016

Finished

Jun 2024

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

16 years and older

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * American Society of Anesthesiologists (ASA) health class I or II * Existing clinical population Exclusion Criteria: * Do not meet the Inclusion Criteria

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Anesthesia Tooth extraction

Contacts and locations

Locations

  • NYCHHC - Jacobi Medical Center and North Central Bronx Hospital

    The Bronx, New York, 10461, United States

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