Collagen pills may boost skin firmness and reduce wrinkles
NCT ID NCT06755892
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tested whether taking collagen supplements daily for 16 weeks can improve skin density, reduce wrinkles, and enhance skin texture in healthy women aged 40 to 65. Participants took either a placebo or one of four collagen-based supplements. The goal was to see if these supplements make skin look and feel younger.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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139 people
The number who actually took part.
- Started
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Jan 2025
- Finished
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Jun 2025
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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40 to 65 years
- Sex
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Female participants only
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion criteria: * Caucasian female volunteers aged between 40 and 65 years at the time of the signature of Informed consent form (ICF), * Signed Informed consent form (ICF), * Fitzpatrick skin phototypes I-IV, * Signs of skin aging, * In good general health condition, * BMI \< 35 * Willingness to avoid a consumption of any food supplements containing methylsulfonylmethane (MSM), antioxidants, collagen and other protein-based food supplements during the study, * Willingness to follow all study procedures and keeping a diary during the study (to follow their compliance and palatability). * Willingness to maintain their living habits and to not begin or change any oestrogen or progesterone therapies, * Willingness to avoid shaving/depilation of their arms during the study, * Willingness not to change cosmetic treatment routine during the study, * Willingness to avoid rejuvenation treatments during the study. Exclusion criteria: * Pregnancy or breastfeeding, * Known or suspected allergy to any ingredient of the tested products, * Changes in dietary habits and dietary supplementation in the last three months prior to inclusion, * Regular use of food supplements containing MSM, antioxidants, collagen or other protein-based food supplements in the last three months prior to inclusion, * Veganism, * Changes in cosmetic facial and body care routine in the last month prior to inclusion, * Diagnosed and uncontrolled/untreated/unregulated disease, * Any clinically significant history of serious metabolic disease, digestive tract disease, liver disease, kidney disease, haematological disease, * Intake of drugs with any impact on skin reactions (e.g., glucocorticoids, antihistamines, and immunomodulators), * Any clinically significant acute or chronic skin diseases, * Skin pigmentation disorders on measuring sites, * Anticipated sunbathing or solarium visits before or during the study, * Invasive rejuvenation treatments (e.g. needle rollers, needle mesotherapy, deep/medium-deep chemical peels, laser therapy etc.) in the last 4 months prior to study entry, * Non-invasive rejuvenation treatments (e.g. radiofrequency, electrotherapy, ultrasound, IPL therapy) in the last month prior to study entry, * Shaving/depilation of the arms in the last 14 days before inclusion, * Mental incapacity that precludes adequate understanding or cooperation.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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VIST - Faculty of Applied Sciences, Institute of Cosmetics
Ljubljana, 1000, Slovenia
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Other studies related to the condition(s) this trial covers.
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