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Can collagen shots smooth scars and wrinkles? new study says maybe.

NCT ID NCT07153393

Symptom relief Sponsor: Centro Studi Dermatologici S.r.l. Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study tested whether injections of a collagen powder (HTIC) from cows could improve the look of scars, skin thinning, and volume loss on the face, neck, chest, and hands. Forty-five adults received a series of small injections under the skin. Researchers measured changes in appearance using a standard scale and also checked for pain and satisfaction. The goal was to see if this simple procedure could offer a safe way to rejuvenate skin without surgery.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Type I bovine collagen (HTIC) injections
What this could lead to
If successful, this could offer a non-surgical option to improve the appearance of scars and age-related skin changes on the face and hands.
What could go wrong
This is a small, single-arm study with no comparison group, so results may not be generalizable. The treatment is cosmetic and not a cure for underlying skin conditions.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

45 people

The number who actually took part.

Started

Jan 2025

Finished

May 2025

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 50 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Adult subjects (age between 18-50 years). 2. Subjects in good health. 3. Subjects that presented skin atrophy from acne scarring, other injury, or photo-aging (from mild to moderate). 4. Subjects with a score at least 2 according to the Modified Fitzpatrick Wrinkle Scale (MFWS). 5. The subject has been informed of the nature of the study, agrees to its provisions and has provided written informed consent, approved by the appropriate Ethics Committee (EC). Exclusion Criteria: Subjects will not be enrolled in the study if any of the exclusion criteria listed below are met: 1. Pregnant or breastfeeding. 2. Subjects that had undergone other medical invasive aesthetic treatments for the last 18 months before the enrolment. 3. Subjects with acne. 4. Subjects with seborrheic skin. 5. Subjects with normotonic, normoelastic, and normotrophic skin. 6. Subjects with autoimmune connective tissue disorders (connectivopathies). 7. Subjects with a tendency to develop hypertrophic or keloid scars. 8. Subjects undergoing immunosuppressive therapy. 9. Any cutaneous pathology of infectious, inflammatory, viral and vascular type affecting the treated area. 10. History of allergy or hypersensitivity to any component of the study devices. 11. Performing permanent filler in the past. 12. Use of any therapeutic agent for photoaging or skin rejuvenation within 15 days from the enrolment. 13. Smoking. 14. Wound healing disorders. 15. Participation in other clinical studies.

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Conditions

The condition(s) this trial relates to.

severe cutaneous adverse reaction skin atrophy

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Atrophic scar Cicatrix Scars Skin aging of face and hands

Contacts and locations

Locations

  • Azienda Ospedaliera Federico II

    Naples, Italy

More trials for these conditions

Other studies related to the condition(s) this trial covers.