Den här översättningen är inte klar ännu. Den här sidan är just nu på engelska.

Gå till den engelska sidan

Cure My Disease

Don't miss your cure!

 Log in / Sign up

Could antibiotics save malnourished kids after hospital?

NCT ID NCT05994742

Disease control Sponsor: Queen Mary University of London Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Aug 26, 2026 · Updated 3 times

Summary

Severe acute malnutrition affects millions of children worldwide and often leads to death after hospital discharge. This phase 3 trial tests whether giving a combination of antibiotics (rifampicin, azithromycin, isoniazid, and vitamin B6) for several weeks can lower the risk of death, re-hospitalization, or poor nutritional recovery. About 674 children aged 6–59 months with complicated malnutrition will be enrolled across multiple sites.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Rifampicin, Azithromycin, Isoniazid, and Pyridoxine (antibiotics and vitamin B6)
What this could lead to
If successful, this could lead to a simple antibiotic regimen that reduces deaths and hospital stays in malnourished children after discharge.
What could go wrong
This is a single trial with 674 children; results may not apply to all settings. Antibiotics can cause side effects or resistance.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 3

Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.

Participants

674 people

The number who actually took part.

Started

Jul 2024

Finished

Jul 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

6 to 59 months

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age 6-59 months, of either sex * Hospitalised with complicated severe acute malnutrition, as per WHO definition * Started transition to RUTF * Caregiver willing and able to attend the study clinic for all visits * Caregiver able and willing to give informed consent Exclusion Criteria: * Any acute or chronic condition which mean that receipt of one or more study interventions, or participation in the trial, would not be advisable.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for Child malnutrition are added.

Vår säkerhetsrekommendation!

Genom att skicka in godkänner du våra Användarvillkor

Conditions

The condition(s) this trial relates to.

Child Nutrition Disorders HIV infectious disease nutritional deficiency disease protein-energy malnutrition Severe Acute Malnutrition

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Child malnutrition Comorbidities and coexisting conditions HIV Severe acute malnutrition

Contacts and locations

Locations

  • Chitungwiza Central Hospital

    Harare, Zimbabwe

  • Coast General

    Mombasa, Kenya

  • Homa Bay

    Homa Bay, Kenya

  • Matero Hospital

    Lusaka, Zambia

  • Mbagathi Hospital

    Mbagathi, Kenya

  • Migori Referral Hospital

    Migori, Kenya

  • Parirenyatwa Hospital

    Harare, Zimbabwe

  • Sally Mugabe Hospital

    Harare, Zimbabwe

  • UTH - University Teaching Hospital

    Lusaka, Zambia

More trials for these conditions

Other studies related to the condition(s) this trial covers.