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Stomach acid drug may change how schizophrenia medication works

NCT ID NCT07262736

Knowledge-focused Sponsor: Universiti Sains Malaysia Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at how a common stomach acid drug, pantoprazole, affects the levels of clozapine, a medication for schizophrenia. Thirty-three healthy volunteers took clozapine alone and again after several days of pantoprazole. Researchers measured drug concentrations in the blood to see if pantoprazole changes clozapine exposure, which could help personalize dosing in the future.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
clozapine and pantoprazole
What this could lead to
If successful, this study could help doctors adjust clozapine doses more safely when patients also take pantoprazole, reducing side effects or treatment failure.
What could go wrong
This is a small, early-phase trial in healthy volunteers, not patients. Results may not directly apply to people with schizophrenia or other medical conditions.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 1

The first testing in people. Mainly checks safety and dose, usually in a small group.

Participants

33 people

The number who actually took part.

Started

Feb 2021

Finished

Feb 2022

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 50 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Healthy adult volunteers aged 18 to 50 years 2. No history of chronic medical or psychiatric disease, as confirmed by baseline medical evaluation, medical history, and electrocardiogram (ECG) 3. No use of any medications for at least two weeks before study initiation Exclusion Criteria: 1. Pregnant or breastfeeding women 2. Current smokers

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Healthy volunteers - male and female

Contacts and locations

Locations

  • Pusat Sejahtera (Kesihatan & Pergigian)

    Pulau Pinang, 11800, Malaysia

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