Stomach acid drug may change how schizophrenia medication works

NCT ID NCT07262736

Completed Knowledge-focused Sponsor: Universiti Sains Malaysia Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at how a common stomach acid drug, pantoprazole, affects the levels of clozapine, a medication for schizophrenia. Thirty-three healthy volunteers took clozapine alone and again after several days of pantoprazole. Researchers measured drug concentrations in the blood to see if pantoprazole changes clozapine exposure, which could help personalize dosing in the future.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: clozapine and pantoprazole
What this could lead to: If successful, this study could help doctors adjust clozapine doses more safely when patients also take pantoprazole, reducing side effects or treatment failure.
What could go wrong: This is a small, early-phase trial in healthy volunteers, not patients. Results may not directly apply to people with schizophrenia or other medical conditions.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HEALTHY VOLUNTEERS - MALE AND FEMALE

Contacts and locations

Locations

Pusat Sejahtera (Kesihatan & Pergigian)

Pulau Pinang, 11800, Malaysia

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