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Fatty meal test reveals how your body clock changes with age

NCT ID NCT04225442

Knowledge-focused Sponsor: University of Pennsylvania Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looks at how age, sex, and eating a fatty meal affect the body's internal daily rhythms, known as the chronobiome. Researchers will compare blood samples from 48 healthy adults, half aged 18-30 and half aged 55-75, to see differences in proteins. The goal is to better understand how these factors influence our biological clocks.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Fatty meal
What this could lead to
If successful, this could help us understand how aging and diet affect daily biological rhythms, potentially guiding future health recommendations.
What could go wrong
This is a small, early-stage observational study with only 48 participants, so findings may not apply broadly. It does not test any treatment.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 48 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jan 2020

Expected to finish

Jun 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 75 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Young: 18-30 years of age, Old: 55-75 years of age 2. Apparent healthy 3. BMI (body mass index) up to 27.4 4. Upper arm with intact skin, i.e. without areas of breached or injured skin visible, for ambulatory blood pressure (ABP) measurements, 5. Own and use a smartphone. Exclusion Criteria: 1. History of severe psychiatric illness or cognitive conditions, for example (mania, schizophrenia, or mental retardation; 2. Shift work, defined as recurring work between 22:00-05:00; 3. A diagnosis of clinically significant obstructive sleep apnea; 4. Serum creatinine \> 1.5 mg/dl in men or \>1.3 mg/del in women; 5. Significant liver disease (\>3x upper limit of normal); 6. Diabetes mellitus; 7. Past diagnosis of gastroesophageal reflux disease, 8. Transmeridian travel across ≥3 time zones in the two weeks before the 48hr deep phenotype sessions; 9. Use of oral or intravenous antibiotics in the 6 months prior to enrollment; 10. Subjects, who have received an experimental drug, used an experimental medical device within 30 days prior to screening, or who gave a blood donation of ≥ one pint within 8 weeks prior to screening; 11. \> 2 drinks of alcohol per day; 12. Use of drugs assessed in the urinary drug test; 13. Nursing or pregnant (pregnancy will be repeatedly assessed at the beginning of each of the four inpatient visits, i.e. prior to the start of blood draws); 14. Use of pacemaker or implantable Cardioverter Defibrillator (ICD); 15. Bilateral mastectomy; 16. History of Raynaud's phenomenon; 17. Known allergy against natural latex rubber (contained in ABP bladder and tubing); 18. Subjects taking medication with alpha-blockers.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Healthy Healthy aging

Contacts and locations

Locations

  • Institute for Translational Medicine and Therapeutics (ITMAT), University of Pennsylvania School of Medicine

    Philadelphia, Pennsylvania, 19104, United States

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