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New study probes immune system in rare disease patients

NCT ID NCT06605378

Knowledge-focused Sponsor: Ensoma Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Aug 18, 2026 · Updated 2 times

Summary

This study looks at how common certain antibodies and inflammatory markers are in people with chronic granulomatous disease (CGD). Researchers will measure levels of adenovirus-fighting antibodies and inflammatory cytokines in blood samples from 60 adults and children with CGD. The goal is to better understand the immune system in CGD, which may help guide future treatments.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 60 people

The number the study aims to enrol. It can still change while the study runs.

Started

Nov 2024

Expected to finish

Dec 2026

An estimate. End dates often move.

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

People with CGD

Ages

Children (under 18), adults (18 to 64) and older adults (65 and over)

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * The participant must have been diagnosed with CGD based on the referring physician's confirmation that NADPH oxidase activity is ≤5% (i.e., the percentage of dihydrorhodamine-positive \[DHR+\] cells is ≤5% by flow cytometry) OR based on confirmed pathogenic mutation in a CGD associated gene (CYBB, CYBA, NCF1, NCF2, NCF4, or CYBC1). * The participant or the participant's legally authorized guardian or representative (if applicable) must be capable of giving signed informed consent. * The participant (with assistance from the participant's legally authorized guardian/representative or primary caregiver, if applicable) must be capable of complying with the requirements and restrictions listed in the protocol and informed consent form (ICF). Exclusion Criteria: * The participant has undergone an allogeneic bone marrow transplant or investigational gene therapy. * The participant is unable to comply with the sample collection procedure based on investigator judgment.

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Conditions

The condition(s) this trial relates to.

chronic granulomatous disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Chronic granulomatous disease (CGD)

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    50 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Great Ormond Street Hospital for Children

    COMPLETED

    London, WC1N 3JH, United Kingdom

  • Home-based telemedicine

    RECRUITING

    Montgomery, Alabama, 36104, United States

  • Home-based telemedicine

    RECRUITING

    Phoenix, Arizona, 85001, United States

  • Home-based telemedicine

    RECRUITING

    Little Rock, Arkansas, 72201, United States

  • Home-based telemedicine

    RECRUITING

    Sacramento, California, 95814, United States

  • Home-based telemedicine

    RECRUITING

    Denver, Colorado, 80202, United States

  • Home-based telemedicine

    RECRUITING

    Hartford, Connecticut, 06103, United States

  • Home-based telemedicine

    RECRUITING

    Dover, Delaware, 19901, United States

  • Home-based telemedicine

    RECRUITING

    Washington D.C., District of Columbia, 20001, United States

  • Home-based telemedicine

    RECRUITING

    Tallahassee, Florida, 32301, United States

  • Home-based telemedicine

    RECRUITING

    Atlanta, Georgia, 30303, United States

  • Home-based telemedicine

    RECRUITING

    Boise, Idaho, 83702, United States

  • Home-based telemedicine

    RECRUITING

    Springfield, Illinois, 62701, United States

  • Home-based telemedicine

    RECRUITING

    Indianapolis, Indiana, 46225, United States

  • Home-based telemedicine

    RECRUITING

    Des Moines, Iowa, 50309, United States

  • Home-based telemedicine

    RECRUITING

    Topeka, Kansas, 66603, United States

  • Home-based telemedicine

    RECRUITING

    Frankfort, Kentucky, 40601, United States

  • Home-based telemedicine

    RECRUITING

    Baton Rouge, Louisiana, 70802, United States

  • Home-based telemedicine

    RECRUITING

    Augusta, Maine, 04330, United States

  • Home-based telemedicine

    RECRUITING

    Annapolis, Maryland, 21401, United States

  • Home-based telemedicine

    RECRUITING

    Boston, Massachusetts, 02210, United States

  • Home-based telemedicine

    RECRUITING

    Lansing, Michigan, 48933, United States

  • Home-based telemedicine

    RECRUITING

    Saint Paul, Minnesota, 55102, United States

  • Home-based telemedicine

    RECRUITING

    Jackson, Mississippi, 39205, United States

  • Home-based telemedicine

    RECRUITING

    Jefferson City, Missouri, 65101, United States

  • Home-based telemedicine

    RECRUITING

    Helena, Montana, 59623, United States

  • Home-based telemedicine

    RECRUITING

    Lincoln, Nebraska, 68502, United States

  • Home-based telemedicine

    RECRUITING

    Carson City, Nevada, 89701, United States

  • Home-based telemedicine

    RECRUITING

    Concord, New Hampshire, 03301, United States

  • Home-based telemedicine

    RECRUITING

    Trenton, New Jersey, 08608, United States

  • Home-based telemedicine

    RECRUITING

    Santa Fe, New Mexico, 87501, United States

  • Home-based telemedicine

    RECRUITING

    Albany, New York, 12207, United States

  • Home-based telemedicine

    RECRUITING

    Bismarck, North Dakota, 58501, United States

  • Home-based telemedicine

    RECRUITING

    Columbus, Ohio, 43215, United States

  • Home-based telemedicine

    RECRUITING

    Oklahoma City, Oklahoma, 73102, United States

  • Home-based telemedicine

    RECRUITING

    Salem, Oregon, 97301, United States

  • Home-based telemedicine

    RECRUITING

    Harrisburg, Pennsylvania, 17101, United States

  • Home-based telemedicine

    RECRUITING

    Providence, Rhode Island, 02903, United States

  • Home-based telemedicine

    RECRUITING

    Columbia, South Carolina, 29217, United States

  • Home-based telemedicine

    RECRUITING

    Pierre, South Dakota, 57501, United States

  • Home-based telemedicine

    RECRUITING

    Nashville, Tennessee, 37219, United States

  • Home-based telemedicine

    RECRUITING

    Austin, Texas, 78701, United States

  • Home-based telemedicine

    RECRUITING

    Salt Lake City, Utah, 84111, United States

  • Home-based telemedicine

    RECRUITING

    Montpelier, Vermont, 05602, United States

  • Home-based telemedicine

    RECRUITING

    Richmond, Virginia, 23219, United States

  • Home-based telemedicine

    RECRUITING

    Olympia, Washington, 98507, United States

  • Home-based telemedicine

    RECRUITING

    Charleston, West Virginia, 25301, United States

  • Home-based telemedicine

    RECRUITING

    Madison, Wisconsin, 53703, United States

  • Home-based telemedicine

    RECRUITING

    Cheyenne, Wyoming, 82001, United States

  • Royal Free London NHS Foundation Trust

    COMPLETED

    London, United Kingdom

  • Science 37, Inc

    RECRUITING

    Morrisville, North Carolina, 27560, United States

  • University of California, San Francisco

    RECRUITING

    San Francisco, California, 94158, United States

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