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Can vitamin c shield the brain from too much oxygen?

NCT ID NCT07369232

Knowledge-focused Sponsor: Erasme University Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at how breathing pure oxygen for 30 minutes affects blood flow and stress in the brain, and whether vitamin C can help. Thirteen healthy adults took part, each receiving either vitamin C or a placebo before oxygen. Researchers measured brain blood flow, skin perfusion, and blood markers. The goal is to better understand oxygen's effects on the brain, not to test a treatment.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Oxygen and vitamin C (ascorbic acid)
What this could lead to
If successful, this could help doctors understand how to use oxygen more safely in hospitals, potentially reducing brain-related side effects.
What could go wrong
This is a very small, early study in healthy volunteers, not patients. Results may not apply to sick people, and the effects may be too subtle to measure reliably.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

13 people

The number who actually took part.

Started

Sep 2025

Finished

Apr 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adults * Otherwise healthy, without known pathologies in the cardiovascular, neurological, immunological, renal hematological, or vascular systems. Exclusion Criteria: * Smokers * Pregnant women * BMI \> 25 * Any reason to avoid vit. C * Any reason to avoid breathing oxygen at high doses

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Conditions

The condition(s) this trial relates to.

Hyperoxia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Antioxidant Cerebral autoregulation Hyperoxemia Oxidative stress OXYGEN

Contacts and locations

Locations

  • Department of Intensive Care - Erasmus Hospital - ULB

    Anderlecht, Brussels Capital, 1070, Belgium

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