Can vitamin c shield the brain from too much oxygen?

NCT ID NCT07369232

Completed Knowledge-focused Sponsor: Erasme University Hospital Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at how breathing pure oxygen for 30 minutes affects blood flow and stress in the brain, and whether vitamin C can help. Thirteen healthy adults took part, each receiving either vitamin C or a placebo before oxygen. Researchers measured brain blood flow, skin perfusion, and blood markers. The goal is to better understand oxygen's effects on the brain, not to test a treatment.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Oxygen and vitamin C (ascorbic acid)
What this could lead to: If successful, this could help doctors understand how to use oxygen more safely in hospitals, potentially reducing brain-related side effects.
What could go wrong: This is a very small, early study in healthy volunteers, not patients. Results may not apply to sick people, and the effects may be too subtle to measure reliably.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Hyperoxia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ANTIOXIDANT CEREBRAL AUTOREGULATION HYPEROXEMIA OXIDATIVE STRESS OXYGEN

Contacts and locations

Locations

Department of Intensive Care - Erasmus Hospital - ULB

Anderlecht, Brussels Capital, 1070, Belgium

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