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Could a common probiotic keep precancerous colon polyps away?

NCT ID NCT07167342

Prevention Sponsor: The Affiliated Hospital of Qingdao University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether taking a probiotic called Clostridium butyricum can prevent colorectal adenomas (precancerous polyps) from returning after they are removed during a colonoscopy. About 294 adults aged 18-75 who have had all visible polyps removed will take either the probiotic or a placebo daily for up to 3 years. They will have yearly colonoscopies to check for new polyps.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Clostridium butyricum (a probiotic bacteria)
What this could lead to
If it works, this could offer a simple, safe way to prevent precancerous colon polyps from returning after removal.
What could go wrong
This is a Phase 4 trial, but probiotics are not proven to prevent polyps. The effect may be small or none, and results may not apply to everyone.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 4

Runs after approval, following long-term safety and how well the treatment works in everyday use.

Participants

About 294 people

The number the study aims to enrol. It can still change while the study runs.

Started

May 2026

Expected to finish

Apr 2030

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 75 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age between 18 and 75 years * No restriction on sex * Boston Bowel Preparation Score (BBPS) ≥ 7 prior to endoscopic procedure * Completed endoscopic resection of colorectal adenomas (including cold snare polypectomy, ESD, EMR, etc.) with no residual adenomas or polyps observed endoscopically * Histologically confirmed adenomas (including tubular, villous, or tubulovillous types) without malignant transformation * Able to take oral medication * Signed informed consent Exclusion Criteria: * Use of probiotics, prebiotics, synbiotics, or antibiotics within 2 weeks prior to enrollment * Presence of psychiatric disorders or other conditions preventing compliance with the intervention * Dysfunction of vital organs (liver, kidney, heart, etc.) deemed unsuitable for clinical study participation after evaluation * Participation in other clinical trials within 3 months prior to enrollment * History of gastrointestinal surgery (excluding endoscopic procedures) * History of inflammatory bowel disease * History of autoimmune diseases * Long-term use of aspirin (≥100 mg/day for over 3 months) or calcium supplements (≥1200 mg/day for over 3 months) * Pregnancy or breastfeeding * Previous treatment for colorectal adenomas (including endoscopic or surgical resection) * Familial adenomatous polyposis (FAP)

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Conditions

The condition(s) this trial relates to.

colorectal adenoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Colorectal adenoma Probiotics

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    2 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Weifang People's Hospital

    RECRUITING

    Weifang, Shandong, China

  • the Affiliated Hospital of QIngdao University

    RECRUITING

    Qingdao, Shandong, 266000, China

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