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Breathing your way to a sharper mind? new study tests combo therapy for memory loss

NCT ID NCT04522791

Disease control Sponsor: University of Rochester Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested whether adding slow, paced breathing exercises to computer-based brain training could improve thinking skills and slow dementia in older adults with mild cognitive impairment. Over 8 weeks, 113 participants either did both breathing and brain training, brain training with relaxation, or just relaxation. Researchers measured changes in heart rate, brain function, and daily living skills over 14 months. The goal was to see if calming the nervous system helps the brain learn better and delay decline.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
resonance frequency breathing training
What this could lead to
If it works, this could point toward a non-drug method to slow memory decline and delay dementia in older adults with mild cognitive impairment.
What could go wrong
This is an early-stage trial with only 113 participants, so results may not apply widely. The intervention is complex and requires daily practice, which may be hard to maintain.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

113 people

The number who actually took part.

Started

Aug 2020

Finished

Feb 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

60 to 89 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. All participants will require a diagnosis of "mild cognitive impairment due to Alzheimer's disease"using the most recent NIA and Alzheimer's Association workshop criteria: 1. Presence of memory complaint, 2. Rey Auditory Verbal Learning Test delayed recall (for memory) \< 6, 3. Montreal Cognitive Assessment (for global cognition) ranged 18 and 25, 4. Activities of Daily Living Questionnaire ≤ 30, 2. Intact score for San Diego Brief Assessment of Capacity to Consent (UBACC). 3. If a participant is on Alzheimer's disease medication (i.e., memantine or cholinesterase inhibitors), antidepressants, anxiolytics, or vascular risk or diseases related medications (e.g., beta- blocker), the dose should be stable for 3 months prior to recruitment. 4. Age 60-89, 5. English-speaking, 6. Adequate visual and hearing acuity for using mobile-based apps and testing by self-report, and 7. Community-dwelling. Exclusion Criteria: 1. Current enrollment in another cognitive improvement study; 2. Uncontrollable symptoms of major depression; 3. Major cerebrovascular and cardiovascular diseases (e.g., congestive heart failure, pacemaker, prior myocardial infarction); 4. Neurological diseases (e.g., Parkinson's disease, Multiple Sclerosis); 5. Having an active legal guardian (indicating impaired capacity for decision making); 6. MRI contraindication (e.g., pacemaker, claustrophobia). 7. Color blindedness 8. Alcohol dependency in the past 5 years that are the main contributor to MCI

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Conditions

The condition(s) this trial relates to.

Alzheimer disease Cognitive Dysfunction

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Healthy aging Mild cognitive impairment

Contacts and locations

Locations

  • Feng Lin

    Rochester, New York, 14642-0001, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.