Den här översättningen är inte klar ännu. Den här sidan är just nu på engelska.

Gå till den engelska sidan

Cure My Disease

Don't miss your cure!

 Log in / Sign up

10,000 women with BRCA mutations join national study to unlock cancer prevention secrets

NCT ID NCT07253051

Knowledge-focused Sponsor: Fondazione Policlinico Universitario Agostino Gemelli IRCCS Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study is collecting health information from 10,000 women in Italy who carry BRCA1 or BRCA2 gene mutations, which raise the risk of certain cancers. Researchers aim to better understand where these mutations are most common and how to improve care. Participants simply provide their medical data through a secure platform; no experimental treatments are given.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this could help identify high-risk areas and improve prevention strategies for BRCA-related cancers.
What could go wrong
This is an observational study, not a treatment trial. It collects data only and does not test any intervention, so direct health benefits are not guaranteed.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 10,000 people

The number the study aims to enrol. It can still change while the study runs.

Started

Apr 2025

Expected to finish

Dec 2045

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

All women who are 18 years of age or older and known to be carriers of a pathogenetic mutation class 4 and 5 of the International Agency of Research on Cancer classification) of the BRCA1 or BRCA2 genes, who signed Informed Consent.

Ages

18 years and older

Sex

Female participants only

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * All women who are 18 years of age or older; * All women who known to be carriers of a pathogenetic mutation class 4 and 5 of the International Agency of Research on Cancer classification) of the BRCA1 or BRCA2 genes. Exclusion Criteria: * Age \< 18 years old; * No pathogenetic mutation carriers.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for BRCA1 mutation are added.

Vår säkerhetsrekommendation!

Genom att skicka in godkänner du våra Användarvillkor

Conditions

The condition(s) this trial relates to.

BRCA1-related cancer predisposition BRCA2-related cancer predisposition

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BRCA1 mutation BRCA2 mutation

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    40 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • ASST Papa Giovanni XXIII

    NOT_YET_RECRUITING

    Bergamo, 24127, Italy

  • AULSS 8 Berica

    NOT_YET_RECRUITING

    Vicenza, 36100, Italy

  • Azienda Ospedaliera Universitaria Integrata

    NOT_YET_RECRUITING

    Verona, 37126, Italy

  • Azienda Ospedaliera Universitaria Policlinico Paolo Giaccone

    NOT_YET_RECRUITING

    Palermo, 90127, Italy

  • Azienda Ospedaliera Universitaria Senese

    NOT_YET_RECRUITING

    Siena, 53100, Italy

  • Azienda Ospedaliera Universitaria di Parma

    NOT_YET_RECRUITING

    Parma, 43126, Italy

  • Azienda Ospedaliero Santa Croce e Carle

    NOT_YET_RECRUITING

    Cuneo, 12100, Italy

  • Azienda Ospedaliero Universitaria Careggi, Oncologia Medica Ginecologica

    NOT_YET_RECRUITING

    Florence, 50134, Italy

  • Azienda Ospedaliero Universitaria Citta della Salute e della Scienza di Torino

    NOT_YET_RECRUITING

    Torino, 10126, Italy

  • Azienda Ospedaliero Universitaria Pisana

    NOT_YET_RECRUITING

    Pisa, 56100, Italy

  • Azienda Ospedaliero-Universitaria di Parma

    NOT_YET_RECRUITING

    Parma, 43126, Italy

  • Azienda ULSS 2 MARCA TREVIGIANA

    NOT_YET_RECRUITING

    Treviso, 31100, Italy

  • Azienda sanitaria universitaria Friuli Centrale

    NOT_YET_RECRUITING

    Tolmezzo, 33028, Italy

  • Centro Nazionale di Adroterapia Oncologica

    NOT_YET_RECRUITING

    Pavia, 27100, Italy

  • Centro di Riferimento Oncologico IRCCS

    NOT_YET_RECRUITING

    Aviano, 33081, Italy

  • Fondazione I.R.C.C.S. Policlinico San Matteo

    NOT_YET_RECRUITING

    Pavia, 27100, Italy

  • Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico

    NOT_YET_RECRUITING

    Milan, 20133, Italy

  • Fondazione IRCCS San Gerardo dei Tintori

    RECRUITING

    Monza, 20900, Italy

  • Fondazione Policlinico Universitario Agostino Gemelli IRCCS, UOC Ginecologia Oncologica

    RECRUITING

    Rome, 00168, Italy

  • Humanitas San Pio X - Milano

    NOT_YET_RECRUITING

    Milan, 20159, Italy

  • IRCCS Istituto Tumori "Giovanni Paolo II"

    RECRUITING

    Bari, 70124, Italy

  • IRCCS Ospedale Policlinico San Martino

    NOT_YET_RECRUITING

    Genova, 16132, Italy

  • IRCCS Ospedale San Raffaele

    NOT_YET_RECRUITING

    Milan, 20132, Italy

  • IRCCS materno infantile Burlo Garofolo

    NOT_YET_RECRUITING

    Trieste, 34137, Italy

  • Istituto Nazionale Tumori Fondazione G. Pascale

    RECRUITING

    Naples, 80131, Italy

  • Istituto Nazionale Tumori Regina Elena

    NOT_YET_RECRUITING

    Roma, 00144, Italy

  • Istituto Nazionale Tumori Regina Elena

    NOT_YET_RECRUITING

    Roma, 00144, Italy

  • Istituto Romagnolo per lo Studio dei Tumori "Dino Amadori"

    NOT_YET_RECRUITING

    Meldola, 47014, Italy

  • L'Azienda ospedaliera per l'emergenza "Cannizzaro"

    NOT_YET_RECRUITING

    Catania, 95126, Italy

  • Malzoni Research Hospital

    NOT_YET_RECRUITING

    Avellino, 83100, Italy

  • Ospedale G. Mazzini di Teramo

    NOT_YET_RECRUITING

    Teramo, 64100, Italy

  • Ospedale Mater Olbia

    NOT_YET_RECRUITING

    Olbia, 07026, Italy

  • Ospedale Mauriziano Umberto I

    NOT_YET_RECRUITING

    Torino, 10128, Italy

  • Ospedale S. Maria Goretti, Latina

    NOT_YET_RECRUITING

    Latina, 04100, Italy

  • Ospedale Vito Fazzi, Lecce

    NOT_YET_RECRUITING

    Lecce, 73100, Italy

  • Ospedale del Tigullio Polo di Lavagna - ASL 4 Chiavarese

    NOT_YET_RECRUITING

    Lavagna, 16033, Italy

  • Policlinico Umberto I Università "La Sapienza"

    NOT_YET_RECRUITING

    Roma, 00161, Italy

  • Presidio Ospedaliero Umberto I - ASP di Enna

    NOT_YET_RECRUITING

    Enna, 94100, Italy

  • Presidio Ospedaliero di Mirano

    NOT_YET_RECRUITING

    Mirano, 30035, Italy

  • Università degli Studi di Bari "Aldo Moro"

    NOT_YET_RECRUITING

    Bari, 70121, Italy

More trials for these conditions

Other studies related to the condition(s) this trial covers.