Can zapping the brain sharpen fading memory?
NCT ID NCT03331796
First seen Jun 25, 2026 · Last updated Jun 26, 2026 · Updated 1 time
Summary
This study tested whether a noninvasive technique called repetitive Transcranial Magnetic Stimulation (rTMS) can improve memory in people with mild cognitive impairment (MCI). 69 participants were randomly assigned to receive active rTMS to one of two brain areas or a placebo treatment. The goal was to see if the stimulation could boost word recall on a memory test.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- repetitive Transcranial Magnetic Stimulation (rTMS)
- What this could lead to
- If it works, this could point toward a non-drug treatment to ease memory problems in people with mild cognitive impairment.
- What could go wrong
- This is a small, early-stage study with only 69 participants. The results may not apply to everyone, and the benefits might be modest or not last long.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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69 people
The number who actually took part.
- Started
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Jun 2018
- Finished
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Mar 2023
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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55 to 90 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
* Both Veterans and Non-Veterans may enroll if they meet the following criteria \*\* Inclusion Criteria: * Diagnosed with amnestic Mild Cognitive Impairment (aMCI); * Stable medications (including any dementia-related meds) for at least 4 weeks prior to Baseline; * Geriatric Depression Scale score less than 6; * Ability to obtain a motor threshold, determined during the screening process; * Study partner available; living situation enables attendance at clinic visits; * Visual and auditory acuity adequate for neuropsychological testing; * Good general health with no diseases expected to interfere with the study; * Participant is not pregnant or of childbearing potential (i.e. women must be 2 years post-menopausal or surgically sterile); * Modified Hachinski Ischemic score less than or equal to 4; * Agree to DNA extraction for single nucleotide polymorphism (SNP) genotyping; * Able to understand study procedures and comply with them for the entire length of the study. Exclusion Criteria: * Prior exposure to rTMS within the past 12 months; * Magnetic field safety concern such as a cardiac pacemaker, cochlear implant, implanted device in the brain (deep brain stimulation), or metal fragments or foreign objects in the eyes, skin or body; * Any significant neurological disease other than suspected incipient Alzheimer's disease; * Unstable cardiac disease or recent (\< 3 months previous) myocardial infarction. Any significant systemic illness or unstable medical condition that could lead to difficulty with protocol adherence; * History of epilepsy or repetitive seizures, as determined by patient report or chart review; * History of a medical condition or current use/abuse of medications and substances that increase the risk of a seizure, specifically: * Traumatic brain injury within 2 months that would increase the risk for seizure; * Unable to safely withdraw, at least 4 weeks prior to Baseline, from medications that substantially increase the risk of having seizures (for example: theophylline, clozapine, and methylphenidate). * Current or past history of a mass lesion, cerebral infarct, or other noncognitive active neurological disease that would increase the risk for seizure. * Stimulant abuse within the previous 90 days. Cocaine and abuse of amphetamine and methylphenidate are associated with an increased risk of seizures; * Major depression or bipolar disorder (DSM-IV) within the past 1 year, or psychotic features within the last 3 months that could lead to difficulty with protocol adherence; * Taking sedative hypnotics or medications with anti-cholinergic properties and unable to withdraw at least 4 weeks prior to Baseline; * Current alcohol or substance abuse (not including caffeine or nicotine) within the past 1 year, as determined by chart review, participant or study partner report, or greater than "moderate" alcohol use defined by the Quantity-Frequency-Variability Index (Cahalan, Cisin, \& Crossley, 1969); * Any contraindications for magnetic resonance imaging (MRI) studies, e.g. severe claustrophobia, weight above 350 lb maximum allowed by MRI scanner, pregnancy; * Participation in another concurrent clinical trial; * Inability or unwillingness of individual or legal representative to give written informed consent.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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VA Palo Alto Health Care System
Palo Alto, California, 94304, United States
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