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When is the best time to zap brain tumors? new trial tests before, during, or after surgery

NCT ID NCT05871307

First seen May 06, 2026 · Last updated Jun 22, 2026 · Updated 5 times

Summary

This trial is testing three different timings for radiotherapy in people with brain metastases who need surgery: before surgery, during surgery, or after surgery. The goal is to see which approach best controls tumor growth and prevents recurrence. About 90 adults with solid tumors that have spread to the brain will take part. The study is active but not recruiting.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • Department of Radiotherapy, University of Heidelberg

    Heidelberg, 69120, Germany

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

Radiotherapy (stereotactic radiosurgery or intraoperative radiation)

What this could lead to

If successful, this trial could identify the optimal timing of radiotherapy for brain metastases, potentially improving local tumor control and reducing side effects.

What could go wrong

This is a small, early-phase (phase II) exploratory trial with only 90 participants. Results may not apply to all patients, and the best timing may still not be clear.

Conditions

The condition(s) this trial relates to.

brain cancer

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.