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Birth control pills and the brain: what happens when you stop?

NCT ID NCT07511439

Knowledge-focused Sponsor: Rigshospitalet, Denmark Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jul 02, 2026 · Updated 1 time

Summary

This study looks at whether stopping combined birth control pills changes a key brain chemical called serotonin, which affects mood and memory. Sixty healthy women aged 18-39 who currently take a specific type of pill will either stop or continue their pill for up to a year. Researchers will use brain scans and memory tests to track any changes.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 4

Runs after approval, following long-term safety and how well the treatment works in everyday use.

Participants

About 60 people

The number the study aims to enrol. It can still change while the study runs.

Started

Apr 2026

Expected to finish

Dec 2030

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 39 years

Sex

Female participants only

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Healthy women (assigned female at birth) at 18-39 years of age 2. Currently using a second-generation combined oral contraceptive containing 150 ug levonorgestrel and 30 ug ethinylestradiol for at least 3 months Exclusion Criteria: 1. Current or previous neurological or psychiatric disease, severe somatic disease, or consumption of medical drugs (including psychoactive medication) likely to influence the test results 2. Non-fluent in Danish or pronounced visual or auditory impairments 3. Current or past learning disability 4. Pregnancy within the last year or previous pregnancy lasting into second or third trimester 5. A wish to become pregnant within the following 12 months 6. Participation in experiments with exposure to radioactivity (\> 10 mSv) within the last year or significant occupational exposure to radioactivity 7. Contraindications for MRI (pacemaker, metal implants, claustrophobia) 8. A history of head injury or concussion resulting in loss of consciousness for more than 2 min 9. Alcohol or drug abuse 10. Drug use other than tobacco and alcohol within the last 30 days 11. Cannabis \> 50 x lifetime 12. Recreational drugs other than cannabis \> 10 x lifetime (for each substance) 13. Nicotine addiction 14. Non-compliance to COC within the last 3 months (i.e., \> 2 missed pills in a cycle) 15. Contraindication for use of combined oral contraception

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Healthy adult females The focus of the study is to investigate reversible effects of combined oral contraceptive use on serotonergic neurotransmission

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Neurobiology Research Unit (NRU)

    RECRUITING

    Copenhagen, 2100, Denmark

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