Brain zap study aims to unlock secrets of dementia and ADD
NCT ID NCT05927974
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study records brain activity from epilepsy patients who already have electrodes implanted for seizure monitoring. While they perform thinking tasks like memory and attention games, researchers watch how different brain areas talk to each other. The goal is to better understand conditions like dementia, ADD, and depression. No new treatment is given; this is pure observation to guide future therapies.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- What this could lead to
- If successful, this research could reveal how brain networks support thinking and memory, pointing toward better treatments for dementia, ADD, and depression.
- What could go wrong
- This is a small, early-stage observational study (30 people) that does not test any treatment. Findings may not apply to all patients or lead directly to new therapies.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Participants
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About 30 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Mar 2023
- Expected to finish
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Jan 2028
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
Patients with epilepsy undergo a routine surgery to implant electrodes into the brain for intracranial monitoring (ICM) to localize areas of the brain producing seizures.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Eligible for surgery based on multi-disciplinary consensus review * Have a diagnosis of medically-refractory epilepsy * A minimum of 18 years of age * Willingness to participate in the paradigms described in the protocol Exclusion Criteria: * Inability to provide full and informed consent * Age younger than 18 * Are not physically able to participate in study-related activities * Major medical or surgical complication
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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University of Alabama at Birmingham
RECRUITINGBirmingham, Alabama, 35233, United States
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