Botox shot into bladder during prostate surgery may ease urgent bathroom trips
NCT ID NCT05878951
First seen Jan 22, 2026 · Last updated Jun 23, 2026 · Updated 18 times
Summary
This study tests whether injecting Botox into the bladder wall during a standard prostate surgery (HoLEP) can better control overactive bladder symptoms like sudden urges to urinate and leakage. About 66 men aged 18-89 with these symptoms will be randomly assigned to get Botox or a placebo during surgery. Researchers will track symptom improvement and side effects for several months.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
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Locations
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Northwestern Medicine
RECRUITINGChicago, Illinois, 60611, United States
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What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Botox (onabotulinumtoxinA)
What this could lead to
If it works, this could offer a way to reduce urgent, frequent urination and leakage in men already undergoing prostate surgery, improving their quality of life.
What could go wrong
This is a small, early-to-mid-stage trial, so results may not apply to all men. Risks include temporary urinary retention, bleeding, or infection after the procedure.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.