Could a simple blood swap cut transfusions in bone cancer surgery?
NCT ID NCT07669155
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether removing some blood during bone cancer surgery and replacing it with fluid (acute normovolemic hemodilution) can reduce the need for donor blood transfusions. The trial will include 420 adults undergoing elective bone cancer surgery. The goal is to see if this technique lowers transfusion rates and related complications.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Acute normovolemic hemodilution (a procedure where some blood is removed during surgery and replaced with fluid, then given back later)
- What this could lead to
- If it works, this technique could reduce the need for donor blood transfusions during bone cancer surgery, lowering risks and costs.
- What could go wrong
- This is an early-stage trial with no results yet. The procedure may not reduce transfusions as hoped, and there are always risks with any surgical technique.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 420 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Jul 2026
An estimate. Start dates often move.
- Expected to finish
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May 2028
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: 1. age 18 more than years; 2. undergoing elective bone cancer resection surgery; 3. preoperative hemoglobin ≥12 g/dL; Exclusion Criteria: 1. using a tourniquet; 2. BMI\<18.5 Kg/m\^2; 3. international normalized ratio (INR) \>1.5 or platelet count \<100 × 10\^9/L; 4. cardiopulmonary insufficiency; 5. hepatic and renal dysfunction; 6. active infectious disease; 7. allergy to colloid solution; 8. pregnancy; 9. declined participation in the study or declined blood transfusion
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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The Second Affiliated Hospital of Zhejiang University anesthesiology department
Hangzhou, Zhejiang, 310000, China
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