Heart surgery fluid trick could cut transfusions and complications

NCT ID NCT07466082

Disease control Sponsor: Bursa City Hospital Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested whether using a device called the Pleth Variability Index (PVI) to guide a blood-saving technique (acute normovolemic hemodilution) during heart surgery leads to better fluid balance and fewer complications. Eighty patients undergoing cardiac surgery were enrolled. The goal was to see if PVI guidance reduces the need for blood transfusions and lowers the risk of problems like kidney injury.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance: acute normovolemic hemodilution (blood removal and fluid replacement)
What this could lead to: If successful, this approach could help heart surgery patients receive fewer blood transfusions and have fewer complications like kidney injury.
What could go wrong: This is a small, completed study with 80 participants, so results may not apply to all heart surgery patients. The technique also carries risks of hemodynamic instability if not managed carefully.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

80 people

The number who actually took part.

Started

Nov 2025

Finished

Mar 2026

Lead sponsor

A government agency

The lead sponsor is a government body.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 85 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * ASA (American Society of Anesthesiologists) score II-III, * ejection fraction (LVEF) \>45%, * NYHA (New York Heart Association) class I-III, * hematocrit value \>35%, * and patients who have not had a myocardial infarction in the last three months. Exclusion Criteria: * Emergency or redo surgery requirement, * LVEF (left ventricular ejection fraction) \<35%, * severe LMCA (left main coronary artery) stenosis (\>70%), * BMI \<18.5, * severe comorbidity (endocarditis, advanced COPD (chronic obstructive pulmonary disease), CKD (chronic kidney disease), anemia, hypoalbuminemia, peripheral artery disease), * active DAPT /heparin use, * coagulopathy, * uncontrolled systemic diseases, * pregnancy, * malignancy

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for Acute normovolemic hemodilution are added.

Vår säkerhetsrekommendation!

Genom att skicka in godkänner du våra Användarvillkor

Conditions

The condition(s) this trial relates to.

Postoperative Complications

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Acute normovolemic hemodilution Cardiac surgery Pleth variability index Postoperative complication

Heart surgery fluid trick could cut transfusions and complications

What the study statuses mean