Beetroot juice may supercharge exercise benefits for seniors

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Male or female aged 60 years or older 2. Free of chronic disease or disorder that would preclude full participation or have the potential to confound results 3. No structured exercise program (2 or more bouts/wk) within previous 12 months 4. Cognitively capable of providing informed consent Exclusion Criteria: 1. BMI ≥ 30.0 kg/m2 2. Neurodegenerative disease 3. Neuromuscular, musculoskeletal or orthopedic disorder or condition that would limit ability to perform the exercise prescription and/or physical performance testing 4. Diagnosed orthostatic hypotension, i.e., a drop in systolic blood pressure of at least 20 mmHg or a drop in diastolic blood pressure of at least 10 mmHg within three minutes of standing up from a sitting or lying position. 5. Resting blood pressure \<90/60 mmHg or \>160/95 mmHg 6. Uncontrolled hypertension 7. Any current cardiovascular disease or cardiopulmonary instability 8. Recent cardiovascular event or procedure within the preceding 6 months 1. If valve replacement has been performed, patient may not be enrolled for 12 months after the procedure 2. Any mechanical valve replacement that requires continuous warfarin anti-coagulation 9. Anemia: Hgb \<11.0 (♂),10.0 (♂) gm/dl 10. Diabetes with HgbA1c \>7.0% or fasting blood glucose ≥ 130 mg/dl 11. Liver disease with ALT \> 52 U/l) 12. Chronic kidney disease (eGFR \< 45) 13. Any current infectious disease 14. Any other disease or disorder that could influence exercise response, preclude full participation or have the potential to confound results (e.g., chronic lung disease, cognitive impairment, current cancer diagnosis or within 2 yr remission, cerebrovascular disease, pain) 15. Life expectancy \< 1 year Medications / lifestyle 16. Insulin sensitizing/blood glucose lowering agents such as metformin 17. Currently on or have used GLP-1 agonist or other metabolic / weight loss drug in previous 12 weeks 18. Use of nitrate medications 19. High dose statin (≥40 mg/d simvastatin equivalence) 20. Chronic corticosteroids 21. Testosterone or other anabolic/androgenic hormone therapy 22. Lidocaine allergy 23. Regular tobacco use and/or vaping \> 1/wk 24. Use of cannabis \> 1/wk 25. Excessive alcohol consumption (3 drinks/d or 7 drinks/wk for females; 4 drinks/d or 14 drinks/wk for males) 26. Use of illicit drugs (e.g., cocaine, opioids) 27. Unable to commit to \~4 months required to complete the study