New combo therapy aims to keep prostate cancer from coming back after surgery

NCT ID NCT03371719

Disease control Sponsor: NRG Oncology Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 28, 2026 · Updated 2 times

Summary

This study is for men whose prostate cancer has returned after prostate removal surgery, shown by a rising PSA. It compares standard radiation therapy alone versus radiation plus a drug called apalutamide, which blocks male hormones that fuel cancer growth. The goal is to see if the combination delays cancer progression longer. About 324 participants will take part, and the study is currently active but no longer recruiting.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2

Tests whether the treatment actually works, and watches for side effects, in a larger group.

Participants

298 people

The number who actually took part.

Started

Jun 2018

Expected to finish

Oct 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Male participants only

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Pathologically (histologically) proven diagnosis of prostate adenocarcinoma; prostatectomy must have been performed within 10 years prior to Step 1 registration and any type of radical prostatectomy is permitted, including retropubic, perineal, laparoscopic or robotically assisted * Post-prostatectomy patients with a detectable serum PSA (\>= 0.1, but =\< 1.0 ng/mL) at study entry (within 90 days of Step 1 registration) and at least one of the following: * Gleason score 7-10 (International Society of Urological Pathology \[ISUP\] grade group 2 to 5) * ISUP grade group: * Grade group 1 = Gleason score =\< 6, * Grade group 2 = Gleason score 3 + 4 = 7, * Grade group 3 = Gleason score 4 + 3 = 7, * Grade group 4 = Gleason score 8, * Grade group 5 = Gleason scores 9 and 10 * \>= T3a disease * Persistent elevation of PSA after prostatectomy measured within 90 days after surgery (PSA never became undetectable) of \> 0.04 but \< 0.2 ng/mL (PSA nadir) * pN0 or pNx * History/physical examination within 90 days prior to Step 1 registration * Karnofsky performance status of 70-100 within 90 days prior to Step 1 registration * Surgical formalin-fixed paraffin-embedded (FFPE) specimen must be available for submission to GenomeDx for genomic analysis on Decipher GRID platform; Note: if Decipher results have already been obtained, in lieu of tissue, results must be submitted to GenomeDx for validation and for GenomeDx to provide the subtyping needed for stratification * Prior androgen deprivation therapy (luteinizing hormone-releasing hormone \[LHRH\] agonist and/or non-steroidal anti-androgen) is allowed if discontinued at least 90 days prior to Step 1 registration and given for =\< 90 days duration * For example: patients on prior LHRH analogs (post-prostatectomy), the discontinuation date should be calculated based on the expected duration of the sustained release injection, not simply the injection date of the drug; for instance, if a 22.5 mg sustained release dose of leuprolide acetate is given (3 month duration), then the expected duration of such a dose would be 90 days after the injection date; for a 7.5 mg leuprolide (1 month duration), the discontinuation date would be 30 days after the injection date * Please note: finasteride or dutasteride must be stopped before treatment starts but prior usage will not affect eligibility * Hemoglobin \>= 9.0 g/dL, independent of transfusion and/or growth factors within 90 days prior to Step 1 registration * Platelet count \>= 100,000 x 10\^9/uL independent of transfusion and/or growth factors within 90 days prior to Step 1 registration * Serum albumin \>= 3.0 g/dL within 90 days prior to Step 1 registration * Glomerular filtration rate (GFR) \>= 35 mL/min estimated by Cockcroft-Gault or measured directly by 24 hour urine creatinine within 90 days prior to Step 1 registration * Serum total bilirubin =\< 1.5 x upper limit of normal (ULN) (Note: in subjects with Gilbert's syndrome, if total bilirubin is \> 1.5 x ULN, measure direct and indirect bilirubin and if direct bilirubin is =\< 1.5 x ULN, subject is eligible) within 90 days prior to Step 1 registration * Aspartate aminotransferase (AST) or alanine aminotransferase (ALT) \< 2.5 x ULN within 90 days prior to Step 1 registration * Testosterone \> 50 ng/dL within 90 days prior to Step 1 registration * Concomitant medications known to lower the seizure threshold discontinued or substituted at least 4 weeks (30 days) prior to Step 1 registration * The patient must agree to use a condom (even men with vasectomies) and another effective method of birth control if he is having sex with a woman of childbearing potential or agree to use a condom if he is having sex with a woman who is pregnant while on study drug and for 3 months following the last dose of study drug * The patient must agree not to donate sperm during the study treatment and for 3 months after receiving the last dose of study drug * The patient or a legally authorized representative must provide study-specific informed consent prior to study entry Exclusion Criteria: * PRIOR TO STEP 1 REGISTRATION: * Definitive clinical, radiologic, or pathologic evidence of metastatic disease (M1) or lymph node involvement (N1) * Prior invasive malignancy (except non-melanomatous skin cancer, carcinoma in situ of the male breast, penis, oral cavity, or stage Ta of the bladder, or stage I completely resected melanoma) unless disease free for a minimum of 2 years * Prior systemic chemotherapy for the study cancer; note that prior chemotherapy for a different cancer is allowable * Prior radiotherapy to the region of the study cancer that would result in overlap of radiation therapy fields * History of any of the following: * Seizure or known condition that may pre-dispose to seizure (e.g. prior stroke within 1 year prior to Step 1 registration) * History of documented inflammatory bowel disease * Transmural myocardial infarction within the last 4 months prior to Step 1 registration * Unstable angina and/or congestive heart failure requiring hospitalization within the last 6 months prior to Step 1 registration * History of any condition that in the opinion of the investigator, would preclude participation in this study * Current evidence of any of the following: * Known gastrointestinal disorder affecting absorption of oral medications * Active uncontrolled infection (e.g., human immunodeficiency virus \[HIV\] or viral hepatitis) * Uncontrolled hypertension * Any current condition that in the opinion of the investigator, would preclude participation in this study * Prior whole gland ablative therapy (i.e. cryoablation or high intensity focused ultrasound \[HIFU\]) for prostate cancer is not allowed * HIV positive with CD4 count \< 200 cells/microliter within 30 days prior to registration * HIV patients under treatment with highly active antiretroviral therapy (HAART) within 30 days prior to registration regardless of CD4 count; (Note: HIV testing is not required for eligibility for this protocol as it is self-reported; this exclusion criterion is necessary because the treatments involved in this protocol may be immunosuppressive and/or interact with HAART) * Patients must not plan to participate in any other clinical trials while receiving treatment on this study or being followed post-protocol therapy * PRIOR TO STEP 2 REGISTRATION: * For patients who have not undergone prior Decipher analysis, submission of the specimen to GenomeDx should be as soon as possible after study registration (Step 1) as these results can take up 21 days after the specimen is received at GenomeDx; Step 2 registration must occur within 6 weeks (42 days) of Step 1 registration; if Decipher results have already been obtained, in lieu of tissue, results must be submitted to GenomeDx for validation

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Conditions

The condition(s) this trial relates to.

metastatic prostate carcinoma prostate adenocarcinoma prostate cancer prostate carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Recurrent prostate carcinoma Stage III prostate adenocarcinoma ajcc V7 Stage IV prostate adenocarcinoma ajcc V7

Contacts and locations

Locations

Abbott-Northwestern Hospital

Minneapolis, Minnesota, 55407, United States
AdventHealth Altamonte

Altamonte Springs, Florida, 32701, United States
AdventHealth East Orlando

Orlando, Florida, 32822, United States
AdventHealth Kissimmee

Kissimmee, Florida, 34744, United States
AdventHealth Orlando

Orlando, Florida, 32803, United States
AdventHealth Winter Park

Winter Park, Florida, 32792, United States
Alegent Health Bergan Mercy Medical Center

Omaha, Nebraska, 68124, United States
Allan Blair Cancer Centre

Regina, Saskatchewan, S4T 7T1, Canada
Alta Bates Summit Medical Center-Herrick Campus

Berkeley, California, 94704, United States
American Fork Hospital / Huntsman Intermountain Cancer Center

American Fork, Utah, 84003, United States
Ann M Wierman MD LTD

Las Vegas, Nevada, 89128, United States
Arizona Center for Cancer Care - Gilbert

Gilbert, Arizona, 85297, United States
Arizona Center for Cancer Care - Scottsdale

Scottsdale, Arizona, 85258, United States
Arizona Center for Cancer Care-Peoria

Peoria, Arizona, 85381, United States
Arizona Center for Cancer Care-Surprise

Surprise, Arizona, 85374, United States
Armes Family Cancer Center

Findlay, Ohio, 45840, United States
Arthur J E Child Comprehensive Cancer Centre

Calgary, Alberta, T2N 5G2, Canada
Asplundh Cancer Pavilion

Willow Grove, Pennsylvania, 19090, United States
Atrium Medical Center-Middletown Regional Hospital

Franklin, Ohio, 45005-1066, United States
Audie L Murphy VA Hospital

San Antonio, Texas, 78229, United States
Augusta University Medical Center

Augusta, Georgia, 30912, United States
Aurora BayCare Medical Center

Green Bay, Wisconsin, 54311, United States
Aurora Cancer Care-Grafton

Grafton, Wisconsin, 53024, United States
Aurora Cancer Care-Kenosha South

Kenosha, Wisconsin, 53142, United States
Aurora Medical Center in Summit

Summit, Wisconsin, 53066, United States
Aurora Saint Luke's Medical Center

Milwaukee, Wisconsin, 53215, United States
Aurora West Allis Medical Center

West Allis, Wisconsin, 53227, United States
Beebe Health Campus

Rehoboth Beach, Delaware, 19971, United States
Benefis Sletten Cancer Institute

Great Falls, Montana, 59405, United States
Billings Clinic Cancer Center

Billings, Montana, 59101, United States
Blanchard Valley Hospital

Findlay, Ohio, 45840, United States
Bozeman Health Deaconess Hospital

Bozeman, Montana, 59715, United States
Bronson Battle Creek

Battle Creek, Michigan, 49017, United States
CHU de Quebec-L'Hotel-Dieu de Quebec (HDQ)

Québec, Quebec, G1R 2J6, Canada
CIUSSSEMTL-Hopital Maisonneuve-Rosemont

Montreal, Quebec, H1T 2M4, Canada
Camden Clark Medical Center

Parkersburg, West Virginia, 26101, United States
Cancer Care and Hematology-Fort Collins

Fort Collins, Colorado, 80528, United States
Cancer Center of Western Wisconsin

New Richmond, Wisconsin, 54017, United States
Cancer Therapy and Integrative Medicine

Las Vegas, Nevada, 89121, United States
Cancer Treatment Centers of America

Tulsa, Oklahoma, 74133, United States
Carle Cancer Center

Urbana, Illinois, 61801, United States
Case Western Reserve University

Cleveland, Ohio, 44106, United States
Cedars Sinai Medical Center

Los Angeles, California, 90048, United States
Central Maryland Radiation Oncology in Howard County

Columbia, Maryland, 21044, United States
Central Vermont Medical Center/National Life Cancer Treatment

Berlin Corners, Vermont, 05602, United States
Centre Hospitalier Universitaire de Sherbrooke-Fleurimont

Sherbrooke, Quebec, J1H 5N4, Canada
Chelsea Hospital

Chelsea, Michigan, 48118, United States
Christiana Care Health System-Christiana Hospital

Newark, Delaware, 19718, United States
Christiana Care Health System-Concord Health Center

Chadds Ford, Pennsylvania, 19317, United States
Cleveland Clinic Akron General

Akron, Ohio, 44307, United States
Cleveland Clinic Cancer Center Mansfield

Mansfield, Ohio, 44906, United States
Cleveland Clinic Cancer Center Strongsville

Strongsville, Ohio, 44136, United States
Cleveland Clinic Cancer Center/Fairview Hospital

Cleveland, Ohio, 44111, United States
Cleveland Clinic Foundation

Cleveland, Ohio, 44195, United States
Cleveland Clinic Wooster Family Health and Surgery Center

Wooster, Ohio, 44691, United States
Cleveland Clinic-Weston

Weston, Florida, 33331, United States
Coborn Cancer Center at Saint Cloud Hospital

Saint Cloud, Minnesota, 56303, United States
Comprehensive Cancer Centers of Nevada

Las Vegas, Nevada, 89148, United States
Comprehensive Cancer Centers of Nevada - Central Valley

Las Vegas, Nevada, 89169, United States
Comprehensive Cancer Centers of Nevada - Henderson

Henderson, Nevada, 89052, United States
Comprehensive Cancer Centers of Nevada - Northwest

Las Vegas, Nevada, 89128, United States
Comprehensive Cancer Centers of Nevada-Horizon Ridge

Henderson, Nevada, 89052, United States
Comprehensive Cancer Centers of Nevada-Southeast Henderson

Henderson, Nevada, 89074, United States
Comprehensive Cancer Centers of Nevada-Summerlin

Las Vegas, Nevada, 89144, United States
Corewell Health Beaumont Troy Hospital

Troy, Michigan, 48085, United States
Corewell Health Dearborn Hospital

Dearborn, Michigan, 48124, United States
Corewell Health Grand Rapids Hospitals - Butterworth Hospital

Grand Rapids, Michigan, 49503, United States
Corewell Health Lakeland Hospitals - Marie Yeager Cancer Center

Saint Joseph, Michigan, 49085, United States
Corewell Health Lakeland Hospitals - Niles Hospital

Niles, Michigan, 49120, United States
Corewell Health Lakeland Hospitals - Saint Joseph Hospital

Saint Joseph, Michigan, 49085, United States
Corewell Health Reed City Hospital

Reed City, Michigan, 49677, United States
Corewell Health William Beaumont University Hospital

Royal Oak, Michigan, 48073, United States
Crossroads Cancer Center

Effingham, Illinois, 62401, United States
Dartmouth Cancer Center - North

Saint Johnsbury, Vermont, 05819, United States
Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center

Lebanon, New Hampshire, 03756, United States
Dayton Physician LLC - Englewood

Dayton, Ohio, 45415, United States
Dayton Physicians LLC - Troy

Troy, Ohio, 45373, United States
Dayton Physicians LLC-Atrium

Franklin, Ohio, 45005, United States
Dayton Physicians LLC-Miami Valley South

Centerville, Ohio, 45459, United States
Dayton Physicians LLC-Wayne

Greenville, Ohio, 45331, United States
Decatur Memorial Hospital

Decatur, Illinois, 62526, United States
Desert West Surgery

Las Vegas, Nevada, 89102, United States
East Jefferson General Hospital

Metairie, Louisiana, 70006, United States
Edward Hines Jr VA Hospital

Hines, Illinois, 60141, United States
Emory Saint Joseph's Hospital

Atlanta, Georgia, 30342, United States
Emory University Hospital Midtown

Atlanta, Georgia, 30308, United States
Emory University Hospital/Winship Cancer Institute

Atlanta, Georgia, 30322, United States
Fairview Clinics and Surgery Center Maple Grove

Maple Grove, Minnesota, 55369, United States
Fairview Lakes Medical Center

Wyoming, Minnesota, 55092, United States
Fairview Ridges Hospital

Burnsville, Minnesota, 55337, United States
Fairview Southdale Hospital

Edina, Minnesota, 55435, United States
Farmington Health Center

Farmington, Utah, 84025, United States
First Dayton Cancer Care

Kettering, Ohio, 45420, United States
Fox Chase Cancer Center

Philadelphia, Pennsylvania, 19111, United States
Froedtert Menomonee Falls Hospital

Menomonee Falls, Wisconsin, 53051, United States
Froedtert West Bend Hospital/Kraemer Cancer Center

West Bend, Wisconsin, 53095, United States
Geauga Hospital

Chardon, Ohio, 44024, United States
Gene Upshaw Memorial Tahoe Forest Cancer Center

Truckee, California, 96161, United States
George Washington University Medical Center

Washington D.C., District of Columbia, 20037, United States
Good Samaritan Hospital - Dayton

Dayton, Ohio, 45406, United States
Goshen Center for Cancer Care

Goshen, Indiana, 46526, United States
Grady Health System

Atlanta, Georgia, 30303, United States
Greater Dayton Cancer Center

Kettering, Ohio, 45409, United States
Greater Regional Medical Center

Creston, Iowa, 50801, United States
Guthrie Medical Group PC-Robert Packer Hospital

Sayre, Pennsylvania, 18840, United States
Health Partners Inc

Minneapolis, Minnesota, 55454, United States
HealthCare Partners Medical Group Oncology/Hematology-Centennial Hills

Las Vegas, Nevada, 89149, United States
HealthCare Partners Medical Group Oncology/Hematology-Maryland Parkway

Las Vegas, Nevada, 89109, United States
HealthCare Partners Medical Group Oncology/Hematology-San Martin

Las Vegas, Nevada, 89113, United States
HealthCare Partners Medical Group Oncology/Hematology-Tenaya

Las Vegas, Nevada, 89128, United States
Helen F Graham Cancer Center

Newark, Delaware, 19713, United States
Hennepin County Medical Center

Minneapolis, Minnesota, 55415, United States
Henry Ford Hospital

Detroit, Michigan, 48202, United States
Henry Ford Macomb Hospital-Clinton Township

Clinton Township, Michigan, 48038, United States
Henry Ford West Bloomfield Hospital

West Bloomfield, Michigan, 48322, United States
Highland Hospital

Rochester, New York, 14620, United States
Hillcrest Hospital Cancer Center

Mayfield Heights, Ohio, 44124, United States
Hope Cancer Care of Nevada

Las Vegas, Nevada, 89103, United States
Hope Cancer Care of Nevada-Pahrump

Pahrump, Nevada, 89048, United States
Hunter Holmes McGuire Veterans Administration Medical Center

Richmond, Virginia, 23249, United States
Huntsman Cancer Institute/University of Utah

Salt Lake City, Utah, 84112, United States
Illinois CancerCare-Peoria

Peoria, Illinois, 61615, United States
Indu and Raj Soin Medical Center

Beavercreek, Ohio, 45431, United States
Intermountain Medical Center

Murray, Utah, 84107, United States
James J Peters VA Medical Center

The Bronx, New York, 10468, United States
Jefferson Torresdale Hospital

Philadelphia, Pennsylvania, 19114, United States
Kansas City Veterans Affairs Medical Center

Kansas City, Missouri, 64128, United States
Kettering Medical Center

Kettering, Ohio, 45429, United States
LDS Hospital

Salt Lake City, Utah, 84143, United States
LSU Healthcare Network / Metairie Multi-Specialty Clinic

Metairie, Louisiana, 70006, United States
Lafayette Family Cancer Center-EMMC

Brewer, Maine, 04412, United States
Lahey Hospital and Medical Center

Burlington, Massachusetts, 01805, United States
Lakeview Hospital

Stillwater, Minnesota, 55082, United States
Las Vegas Cancer Center-Henderson

Henderson, Nevada, 89052, United States
Las Vegas Cancer Center-Medical Center

Las Vegas, Nevada, 89148-2405, United States
Laura and Isaac Perlmutter Cancer Center at NYU Langone

New York, New York, 10016, United States
Legacy Good Samaritan Hospital and Medical Center

Portland, Oregon, 97210, United States
Legacy Mount Hood Medical Center

Gresham, Oregon, 97030, United States
Legacy Salmon Creek Hospital

Vancouver, Washington, 98686, United States
Lewis Cancer and Research Pavilion at Saint Joseph's/Candler

Savannah, Georgia, 31405, United States
Logan Regional Hospital

Logan, Utah, 84321, United States
Los Angeles General Medical Center

Los Angeles, California, 90033, United States
Lowell General Hospital

Lowell, Massachusetts, 01854, United States
Loyola University Medical Center

Maywood, Illinois, 60153, United States
MU Health Care Goldschmidt Cancer Center

Jefferson City, Missouri, 65109, United States
MaineHealth Cancer Care Center of York County

Sanford, Maine, 04073, United States
MaineHealth Cancer Care and IV Therapy - Sanford

Sanford, Maine, 04073, United States
MaineHealth Cancer Care and IV Therapy - South Portland

South Portland, Maine, 04106, United States
MaineHealth Coastal Cancer Treatment Center

Bath, Maine, 04530, United States
MaineHealth Maine Medical Center - Biddeford

Biddeford, Maine, 04005, United States
MaineHealth Maine Medical Center - Portland

Portland, Maine, 04102, United States
MaineHealth Maine Medical Center- Scarborough

Scarborough, Maine, 04074, United States
MaineHealth Stephens Hospital

Norway, Maine, 04268, United States
MaineHealth Waldo Hospital

Belfast, Maine, 04915, United States
Marin General Hospital

Greenbrae, California, 94904, United States
Marshfield Medical Center - Minocqua

Minocqua, Wisconsin, 54548, United States
Marshfield Medical Center - Weston

Weston, Wisconsin, 54476, United States
Marshfield Medical Center-EC Cancer Center

Eau Claire, Wisconsin, 54701, United States
Marshfield Medical Center-Marshfield

Marshfield, Wisconsin, 54449, United States
Marshfield Medical Center-Rice Lake

Rice Lake, Wisconsin, 54868, United States
Marshfield Medical Center-River Region at Stevens Point

Stevens Point, Wisconsin, 54482, United States
Mary Bird Perkins Cancer Center

Baton Rouge, Louisiana, 70809, United States
Mary Imogene Bassett Hospital

Cooperstown, New York, 13326, United States
Mayo Clinic Health System in Albert Lea

Albert Lea, Minnesota, 56007, United States
Mayo Clinic Health Systems-Mankato

Mankato, Minnesota, 56001, United States
Mayo Clinic in Rochester

Rochester, Minnesota, 55905, United States
McKay-Dee Hospital Center

Ogden, Utah, 84403, United States
Medical Center of the Rockies

Loveland, Colorado, 80538, United States
Medical College of Wisconsin

Milwaukee, Wisconsin, 53226, United States
Memorial Hospital North

Colorado Springs, Colorado, 80920, United States
Mercy Cancer Center - Cape Girardeau

Cape Girardeau, Missouri, 63703, United States
Mercy Cancer Center-West Lakes

Clive, Iowa, 50325, United States
Mercy Hospital

Coon Rapids, Minnesota, 55433, United States
Mercy Hospital Saint Louis

St Louis, Missouri, 63141, United States
Mercy Medical Center - Des Moines

Des Moines, Iowa, 50314, United States
Mercy Medical Center-West Lakes

West Des Moines, Iowa, 50266, United States
Miami Valley Hospital

Dayton, Ohio, 45409, United States
Miami Valley Hospital North

Dayton, Ohio, 45415, United States
Miami Valley Hospital South

Centerville, Ohio, 45459, United States
Michigan Healthcare Professionals Clarkston

Clarkston, Michigan, 48346, United States
Michigan Healthcare Professionals Farmington

Farmington Hills, Michigan, 48334, United States
Michigan Healthcare Professionals Troy

Troy, Michigan, 48098, United States
Michigan State University

East Lansing, Michigan, 48823, United States
Minneapolis VA Medical Center

Minneapolis, Minnesota, 55417, United States
Minnesota Oncology Hematology PA-Maplewood

Maplewood, Minnesota, 55109, United States
Minnesota Oncology Hematology PA-Woodbury

Woodbury, Minnesota, 55125, United States
Monticello Cancer Center

Monticello, Minnesota, 55362, United States
Munson Medical Center

Traverse City, Michigan, 49684, United States
Naval Medical Center - Portsmouth

Portsmouth, Virginia, 23708-2197, United States
Nebraska Methodist Hospital

Omaha, Nebraska, 68114, United States
New Hampshire Oncology Hematology PA-Concord

Concord, New Hampshire, 03301, United States
New Mexico Oncology Hematology Consultants

Albuquerque, New Mexico, 87109, United States
New York-Presbyterian/Brooklyn Methodist Hospital

Brooklyn, New York, 11215, United States
North Coast Cancer Care

Sandusky, Ohio, 44870, United States
North Memorial Medical Health Center

Robbinsdale, Minnesota, 55422, United States
Northeast Radiation Oncology Center

Dunmore, Pennsylvania, 18512, United States
Northside Hospital

Atlanta, Georgia, 30342, United States
Novant Cancer Institute Radiation Oncology - Supply

Supply, North Carolina, 28462, United States
Novant Health Cancer Institute Radiation Oncology - Wilmington

Wilmington, North Carolina, 28401, United States
Novant Health New Hanover Regional Medical Center

Wilmington, North Carolina, 28401, United States
OSF Saint Francis Medical Center

Peoria, Illinois, 61637, United States
OSF Saint Francis Radiation Oncology at Peoria Cancer Center

Peoria, Illinois, 61615, United States
Ohio State University Comprehensive Cancer Center

Columbus, Ohio, 43210, United States
Oncology Hematology Care Inc-Kenwood

Cincinnati, Ohio, 45236, United States
Oncology Las Vegas - Henderson

Henderson, Nevada, 89074, United States
Oncology Las Vegas - Tenaya

Las Vegas, Nevada, 89128, United States
OptumCare Cancer Care at Charleston

Las Vegas, Nevada, 89102, United States
OptumCare Cancer Care at Fort Apache

Las Vegas, Nevada, 89148, United States
OptumCare Cancer Care at MountainView

Las Vegas, Nevada, 89128, United States
OptumCare Cancer Care at Seven Hills

Henderson, Nevada, 89052, United States
Orion Cancer Care

Findlay, Ohio, 45840, United States
Park Nicollet Clinic - Saint Louis Park

Saint Louis Park, Minnesota, 55416, United States
Parkview Hospital Randallia

Fort Wayne, Indiana, 46805, United States
Parkview Regional Medical Center

Fort Wayne, Indiana, 46845, United States
PeaceHealth Saint Joseph Medical Center

Bellingham, Washington, 98225, United States
Penn State Milton S Hershey Medical Center

Hershey, Pennsylvania, 17033-0850, United States
Penobscot Bay Medical Center

Rockport, Maine, 04856, United States
Penrose-Saint Francis Healthcare

Colorado Springs, Colorado, 80907, United States
Phelps Health Delbert Day Cancer Institute

Rolla, Missouri, 65401, United States
Poudre Valley Hospital

Fort Collins, Colorado, 80524, United States
Prisma Health Cancer Institute - Eastside

Greenville, South Carolina, 29615, United States
Prisma Health Cancer Institute - Faris

Greenville, South Carolina, 29605, United States
Prisma Health Cancer Institute - Greer

Greer, South Carolina, 29650, United States
Prisma Health Cancer Institute - Seneca

Seneca, South Carolina, 29672, United States
Prisma Health Cancer Institute - Spartanburg

Boiling Springs, South Carolina, 29316, United States
Providence Saint Mary Regional Cancer Center

Walla Walla, Washington, 99362, United States
Radiation Oncology Associates

Reno, Nevada, 89509, United States
Radiation Oncology Centers of Nevada Central

Las Vegas, Nevada, 89106, United States
Radiation Oncology Centers of Nevada Southeast

Las Vegas, Nevada, 89119, United States
Rapid City Regional Hospital

Rapid City, South Dakota, 57701, United States
Reading Hospital

West Reading, Pennsylvania, 19611, United States
Regional Cancer Center-Lee Memorial Health System

Fort Myers, Florida, 33905, United States
Regions Hospital

Saint Paul, Minnesota, 55101, United States
Reid Health

Richmond, Indiana, 47374, United States
Rice Memorial Hospital

Willmar, Minnesota, 56201, United States
Ridgeview Medical Center

Waconia, Minnesota, 55387, United States
Riverton Hospital

Riverton, Utah, 84065, United States
Robert Wood Johnson University Hospital Somerset

Somerville, New Jersey, 08876, United States
Rush MD Anderson Cancer Center

Chicago, Illinois, 60612, United States
Rutgers Cancer Institute of New Jersey

New Brunswick, New Jersey, 08903, United States
Saint Agnes Hospital

Baltimore, Maryland, 21229, United States
Saint Francis Regional Medical Center

Shakopee, Minnesota, 55379, United States
Saint George Regional Medical Center

St. George, Utah, 84770, United States
Saint John's Hospital - Healtheast

Maplewood, Minnesota, 55109, United States
Saint Luke's Cancer Institute - Boise

Boise, Idaho, 83712, United States
Saint Luke's Cancer Institute - Fruitland

Fruitland, Idaho, 83619, United States
Saint Luke's Cancer Institute - Meridian

Meridian, Idaho, 83642, United States
Saint Luke's Cancer Institute - Nampa

Nampa, Idaho, 83687, United States
Saint Luke's Cancer Institute - Twin Falls

Twin Falls, Idaho, 83301, United States
Saint Luke's University Hospital-Bethlehem Campus

Bethlehem, Pennsylvania, 18015, United States
Salina Regional Health Center

Salina, Kansas, 67401, United States
Sandra L Maxwell Cancer Center

Cedar City, Utah, 84720, United States
Sands Cancer Center

Canandiaqua, New York, 14424, United States
Saskatoon Cancer Centre

Saskatoon, Saskatchewan, S7N 4H4, Canada
Self Regional Healthcare

Greenwood, South Carolina, 29646, United States
Sidney Kimmel Cancer Center Washington Township

Sewell, New Jersey, 08080, United States
Siteman Cancer Center at Saint Peters Hospital

City of Saint Peters, Missouri, 63376, United States
Siteman Cancer Center at West County Hospital

Creve Coeur, Missouri, 63141, United States
Siteman Cancer Center-South County

St Louis, Missouri, 63129, United States
Solinsky Center for Cancer Care

Manchester, New Hampshire, 03103, United States
Southern Illinois University School of Medicine

Springfield, Illinois, 62702, United States
Southwestern Vermont Medical Center

Bennington, Vermont, 05201, United States
Springfield Clinic

Springfield, Illinois, 62702, United States
Springfield Memorial Hospital

Springfield, Illinois, 62781, United States
Springfield Regional Cancer Center

Springfield, Ohio, 45504, United States
Springfield Regional Medical Center

Springfield, Ohio, 45504, United States
Stamford Hospital/Bennett Cancer Center

Stamford, Connecticut, 06904, United States
State University of New York Upstate Medical University

Syracuse, New York, 13210, United States
Stony Brook University Medical Center

Stony Brook, New York, 11794, United States
Summa Health System - Akron Campus

Akron, Ohio, 44304, United States
Summerlin Hospital Medical Center

Las Vegas, Nevada, 89144, United States
Sutter Cancer Centers Radiation Oncology Services-Roseville

Roseville, California, 95661, United States
Sutter Medical Center Sacramento

Sacramento, California, 95816, United States
Sutter Solano Medical Center/Cancer Center

Vallejo, California, 94589, United States
The Mark H Zangmeister Center

Columbus, Ohio, 43219, United States
The Radiation Oncology Center-Hilton Head/Bluffton

Hilton Head Island, South Carolina, 29926, United States
The Research Institute of the McGill University Health Centre (MUHC)

Montreal, Quebec, H3H 2R9, Canada
The University of Kansas Cancer Center - Olathe

Olathe, Kansas, 66061, United States
The West Clinic - Wolf River

Germantown, Tennessee, 38138, United States
Thomas Jefferson University Hospital

Philadelphia, Pennsylvania, 19107, United States
Trinity Health Grand Rapids Hospital

Grand Rapids, Michigan, 49503, United States
Trinity Health Medical Center - Brighton

Brighton, Michigan, 48114, United States
Trinity Health Medical Center - Canton

Canton, Michigan, 48188, United States
Trinity Health Saint Joseph Mercy Hospital Ann Arbor

Ann Arbor, Michigan, 48106, United States
UCHealth Greeley Hospital

Greeley, Colorado, 80631, United States
UCHealth Memorial Hospital Central

Colorado Springs, Colorado, 80909, United States
UCHealth University of Colorado Hospital

Aurora, Colorado, 80045, United States
UH Seidman Cancer Center at Firelands Regional Medical Center

Sandusky, Ohio, 44870, United States
UH Seidman Cancer Center at Lake Health Mentor Campus

Mentor, Ohio, 44060, United States
UH Seidman Cancer Center at Southwest General Hospital

Middleburg Heights, Ohio, 44130, United States
UHHS-Chagrin Highlands Medical Center

Beachwood, Ohio, 44122, United States
UHHS-Westlake Medical Center

Westlake, Ohio, 44145, United States
UI Health Care Mission Cancer and Blood - Laurel Clinic

Des Moines, Iowa, 50314, United States
UI Health Care Mission Cancer and Blood - West Des Moines Clinic

Clive, Iowa, 50325, United States
UM Baltimore Washington Medical Center/Tate Cancer Center

Glen Burnie, Maryland, 21061, United States
UNC Lineberger Comprehensive Cancer Center

Chapel Hill, North Carolina, 27599, United States
UPMC Altoona

Altoona, Pennsylvania, 16601, United States
UPMC Cancer Center - Monroeville

Monroeville, Pennsylvania, 15146, United States
UPMC Cancer Center at UPMC Horizon

Farrell, Pennsylvania, 16121, United States
UPMC Cancer Center at UPMC McKeesport

McKeesport, Pennsylvania, 15132, United States
UPMC Cancer Center at UPMC Northwest

Seneca, Pennsylvania, 16346, United States
UPMC Cancer Centers - Arnold Palmer Pavilion

Greensburg, Pennsylvania, 15601, United States
UPMC Hillman Cancer Center in Coraopolis

Moon Township, Pennsylvania, 15108, United States
UPMC Pinnacle Cancer Center/Community Osteopathic Campus

Harrisburg, Pennsylvania, 17109, United States
UPMC Uniontown Hospital Radiation Oncology

Uniontown, Pennsylvania, 15401, United States
UPMC Washington Hospital Radiation Oncology

Washington, Pennsylvania, 15301, United States
UPMC-Heritage Valley Health System Beaver

Beaver, Pennsylvania, 15009, United States
UPMC-Johnstown/John P. Murtha Regional Cancer Center

Johnstown, Pennsylvania, 15901, United States
UPMC-Magee Womens Hospital

Pittsburgh, Pennsylvania, 15213, United States
UPMC-Passavant Hospital

Pittsburgh, Pennsylvania, 15237, United States
UPMC-Saint Clair Hospital Cancer Center

Pittsburgh, Pennsylvania, 15243, United States
UPMC-Saint Margaret

Pittsburgh, Pennsylvania, 15215, United States
UPMC-Shadyside Hospital

Pittsburgh, Pennsylvania, 15232, United States
USC / Norris Comprehensive Cancer Center

Los Angeles, California, 90033, United States
UT Southwestern/Simmons Cancer Center-Dallas

Dallas, Texas, 75390, United States
United Hospital

Saint Paul, Minnesota, 55102, United States
Unity Hospital

Fridley, Minnesota, 55432, United States
University Cancer Center

Las Vegas, Nevada, 89169, United States
University Health Network-Princess Margaret Hospital

Toronto, Ontario, M5G 2M9, Canada
University Hospitals Parma Medical Center

Parma, Ohio, 44129, United States
University Hospitals Portage Medical Center

Ravenna, Ohio, 44266, United States
University Medical Center of Southern Nevada

Las Vegas, Nevada, 89102, United States
University of Arkansas for Medical Sciences

Little Rock, Arkansas, 72205, United States
University of California Davis Comprehensive Cancer Center

Sacramento, California, 95817, United States
University of Cincinnati Cancer Center-UC Medical Center

Cincinnati, Ohio, 45219, United States
University of Cincinnati Cancer Center-West Chester

West Chester, Ohio, 45069, United States
University of Illinois

Chicago, Illinois, 60612, United States
University of Kansas Cancer Center

Kansas City, Kansas, 66160, United States
University of Kansas Cancer Center - Lee's Summit

Lee's Summit, Missouri, 64064, United States
University of Kansas Cancer Center - North

Kansas City, Missouri, 64154, United States
University of Kansas Cancer Center-Overland Park

Overland Park, Kansas, 66210, United States
University of Kansas Hospital-Westwood Cancer Center

Westwood, Kansas, 66205, United States
University of Kentucky/Markey Cancer Center

Lexington, Kentucky, 40536, United States
University of Maryland/Greenebaum Cancer Center

Baltimore, Maryland, 21201, United States
University of Michigan Health - Sparrow Lansing

Lansing, Michigan, 48912, United States
University of Michigan Health - West

Wyoming, Michigan, 49519, United States
University of Michigan Rogel Cancer Center

Ann Arbor, Michigan, 48109, United States
University of Mississippi Medical Center

Jackson, Mississippi, 39216, United States
University of Nebraska Medical Center

Omaha, Nebraska, 68198, United States
University of New Mexico Cancer Center

Albuquerque, New Mexico, 87106, United States
University of Oklahoma Health Sciences Center

Oklahoma City, Oklahoma, 73104, United States
University of Rochester

Rochester, New York, 14642, United States
University of Texas Health Science Center at San Antonio

San Antonio, Texas, 78229, United States
University of Vermont Medical Center

Burlington, Vermont, 05401, United States
University of Vermont and State Agricultural College

Burlington, Vermont, 05405, United States
Upper Valley Medical Center

Troy, Ohio, 45373, United States
Utah Cancer Specialists-Salt Lake City

Salt Lake City, Utah, 84106, United States
Utah Valley Regional Medical Center

Provo, Utah, 84604, United States
Valley View Hospital Cancer Center

Glenwood Springs, Colorado, 81601, United States
Vanderbilt University/Ingram Cancer Center

Nashville, Tennessee, 37232, United States
Vince Lombardi Cancer Clinic - Oshkosh

Oshkosh, Wisconsin, 54904, United States
Vince Lombardi Cancer Clinic-Sheboygan

Sheboygan, Wisconsin, 53081, United States
Vince Lombardi Cancer Clinic-Two Rivers

Two Rivers, Wisconsin, 54241, United States
Virtua Memorial

Mount Holly, New Jersey, 08060, United States
Washington University School of Medicine

St Louis, Missouri, 63110, United States
Wayne Hospital

Greenville, Ohio, 45331, United States
West Michigan Cancer Center

Kalamazoo, Michigan, 49007, United States
West Virginia University Healthcare

Morgantown, West Virginia, 26506, United States
Wilmot Cancer Institute Radiation Oncology at Greece

Rochester, New York, 14606, United States
Zablocki Veterans Administration Medical Center

Milwaukee, Wisconsin, 53295, United States

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