Nrg Oncology

This study compares a standard course of radiation therapy (given over several weeks) with a much shorter course (just a few treatments) for people with muscle invasive bladder cancer. Both groups also receive chemotherapy. The goal is to see if the shorter radiation schedule wor…

This study compares two radiation treatments for people with small cell lung cancer that has spread to the brain. One treatment uses precise, high-dose radiation only on the tumors, while the other treats the whole brain but avoids the memory center. The goal is to see which appr…

This study is for people with early-stage, hormone-sensitive breast cancer who have had a lumpectomy. It compares two approaches: hormone therapy alone versus hormone therapy plus radiation. The goal is to see if skipping radiation is just as effective at preventing the cancer fr…

This study is for people with advanced kidney cancer that has spread and cannot be removed by surgery. It tests whether adding a precise, high-dose form of radiation (SABR) to the main tumor, alongside standard immunotherapy drugs, can better control the cancer and delay its grow…

This study tests whether giving a higher dose of radiation can help people with locally advanced pancreatic cancer live longer. Participants must have already had 4-6 months of chemotherapy. The trial compares the higher-dose radiation to standard care, which may include more che…

This study looks at whether giving radiation therapy after completely removing a grade II meningioma (a type of brain tumor) helps keep the tumor from coming back, compared to simply monitoring with scans. About 163 people with newly diagnosed, fully removed tumors will be random…

This study looks at premenopausal women with a common type of early breast cancer (ER-positive, HER2-negative). It compares two treatments: hormone therapy alone versus hormone therapy plus chemotherapy. The goal is to see if adding chemotherapy helps prevent the cancer from comi…

This study looks at whether a blood test that finds tiny bits of tumor DNA can help doctors choose the right chemotherapy for people with stage III colon cancer after surgery. About 1,900 participants will be assigned to get chemo right away or wait based on test results. The goa…

This study is for people with advanced liver cancer that has spread to nearby blood vessels. It compares standard immunotherapy drugs alone versus immunotherapy plus a precise, high-dose form of radiation called SBRT. The goal is to see if adding radiation helps patients live lon…

This study tests whether adding the drug apalutamide to usual hormone therapy and radiation can keep prostate cancer from spreading in men whose cancer reached lymph nodes after prostate removal surgery. About 586 men will be randomly assigned to get either standard treatment alo…

This study tests if a less invasive procedure called sentinel lymph node biopsy works as well as the standard neck dissection for early-stage oral cavity cancer. The sentinel biopsy removes only a few key lymph nodes, which may reduce side effects like shoulder pain and stiffness…

This study compares a new, shorter radiation treatment (5 sessions over 2 weeks) to the standard longer treatment (20 to 45 sessions over 4 to 9 weeks) for men with high-risk prostate cancer. The goal is to see if the shorter course works just as well at preventing the cancer fro…

This study tests whether newer targeted therapies can better control advanced salivary gland cancer that has spread or cannot be removed. About 146 adults with HER2-positive or HER2-low tumors will receive either standard chemo plus trastuzumab, or one of two antibody-drug conjug…

This study looks at whether taking the drug olaparib for one year is as good as taking it for two years to keep ovarian cancer from coming back. It includes people with advanced ovarian cancer who have certain gene changes (BRCA or HRD). The goal is to find the best treatment len…

This study tests whether adding a precise, high-dose radiation treatment (SBRT) to the tumor before standard chemoradiation and immunotherapy can help people with locally advanced lung cancer live longer. About 474 adults whose lung cancer has spread to nearby lymph nodes but can…

This study tests if a precise type of proton radiation (pCSI) can help people with breast or lung cancer that has spread to the fluid-filled space around the brain and spinal cord live longer than standard x-ray radiation. About 115 participants will be randomly assigned to one o…

This study compares two radiation techniques for people with stage I to IVA esophageal cancer: proton beam therapy (PBT) and intensity modulated photon radiotherapy (IMRT). The goal is to see which one helps patients live longer and causes fewer serious heart and lung side effect…

This study looks at two surgeries for women with BRCA1 gene mutations who are at high risk for ovarian cancer. One surgery removes only the fallopian tubes, while the other removes both tubes and ovaries. The goal is to see if removing just the tubes works nearly as well at preve…

This study looks at whether people who had 1 or 2 small, non-cancerous polyps removed can safely wait 10 years for their next colonoscopy instead of the usual 5 years. About 9,500 adults aged 45-69 will be randomly assigned to have a colonoscopy at 5 and 10 years or only at 10 ye…

This study tests two phone-based programs to help cancer patients manage symptoms and emotional distress while taking oral anti-cancer drugs. One program uses automated calls to track symptoms and share them with the care team. The other adds a self-help handbook and counseling f…

This study tests whether a less invasive lymph node procedure (sentinel mapping) can lower the risk of long-term leg swelling compared to standard lymph node removal. About 428 women with stage I endometrial cancer will be followed for 18 months after hysterectomy. The goal is to…

This study compares two types of radiation therapy for people whose cancer has spread to the brain. One group gets a single high dose of radiation, while the other gets three smaller doses over several days. The goal is to see if the three-dose approach works better at controllin…

This study tests two digital mindfulness programs—one live on Zoom and one self-paced app—to see if they can reduce depression in younger breast cancer survivors (diagnosed at or before age 50). About 402 women who finished primary cancer treatment at least 6 months ago and have …

This study tests if computer-based cognitive training can improve memory and thinking problems in breast cancer survivors. About 386 women who finished treatment for early-stage breast cancer will be randomly assigned to either a brain-training program or a placebo. The goal is t…

This study tests if adding BMX-001 to standard care can reduce severe mouth sores caused by chemoradiation in head and neck cancer patients. About 98 adults will receive either BMX-001 or a placebo alongside their usual treatment. The goal is to see if BMX-001 helps prevent painf…