Nrg Oncology

This study aimed to test whether adding a special virus (Toca 511) and a fungus-fighting drug (Toca FC) to standard chemotherapy and radiation could help people with newly diagnosed glioblastoma, an aggressive brain cancer. The virus was designed to make cancer cells convert the …

This study compares two ways of giving the chemotherapy drug cisplatin along with radiation for people with advanced head and neck cancer. One group gets a high dose every three weeks, the other gets a lower dose weekly. The goal is to see which schedule causes fewer side effects…

This study tests whether adding the drug relugolix to standard radiation therapy can delay cancer growth in men with prostate cancer that has spread to a few other body spots. Relugolix lowers testosterone, which some cancer cells need to grow. About 194 men will receive either r…

This study looks at whether adding a drug called apalutamide to standard radiation therapy can better control prostate cancer that has come back after surgery. About 324 men with a rising PSA after prostate removal will receive either radiation plus apalutamide or radiation plus …

This study tests whether men with high-risk prostate cancer can receive treatment tailored to their genetic risk score. Those with a low genetic risk may get a shorter course of hormone therapy (12 months instead of 24) plus radiation, while those with a high genetic risk get an …

This study tests whether adding a second chemotherapy drug (lomustine) to the standard treatment (temozolomide plus radiation) helps people with a specific type of glioblastoma, a fast-growing brain cancer. The trial includes 265 adults whose tumors have a genetic marker (MGMT me…

This study tests whether giving radiation before surgery for brain metastases is better than after surgery. It includes 237 adults with 1-4 brain tumors, one of which needs removal. The goal is to see if pre-surgery radiation lowers the chance of tumors coming back or spreading, …

This study compares two radiation therapies for people with liver cancer that cannot be removed by surgery or has come back. One uses standard X-rays (photons), the other uses proton beams that stop after the tumor, possibly causing less harm to healthy tissue. The goal is to see…

This study tests whether using a genetic test (Decipher score) to guide prostate cancer treatment can improve outcomes. About 2,050 men with unfavorable intermediate-risk prostate cancer will be assigned to either more intense treatment (adding darolutamide to hormone therapy and…

This study tests whether a blood test for Epstein-Barr virus (EBV) DNA can help doctors choose the best chemotherapy for people with advanced nasopharyngeal cancer. After standard radiation and chemo, patients with no detectable EBV DNA are randomly assigned to either more chemo …

This study looks at whether women and men aged 40+ with early-stage, low-risk HER2-positive breast cancer can safely skip radiation after breast-conserving surgery if they have already received chemotherapy and HER2-targeted therapy. About 1,300 participants will be randomly assi…

This early-phase trial studies a new treatment for people with advanced esophageal or gastroesophageal cancer who cannot have surgery. It combines a cancer-killing virus (OBP-301) with standard chemotherapy and radiation. The main goal is to check safety and find the best dose, w…

This study tests whether giving a higher, more focused dose of radiation (using advanced photon or proton beams) along with the chemotherapy drug temozolomide helps people with newly diagnosed glioblastoma live longer compared to standard radiation. About 600 participants are enr…

This study tests whether adding local treatments like radiation or surgery to standard maintenance chemotherapy helps people with stage IV non-small cell lung cancer live longer without the disease getting worse. About 218 participants are randomly assigned to receive either chem…

This study tests whether giving radiation therapy to high-risk but painless bone tumors can prevent future fractures, spinal cord pressure, or the need for surgery. About 280 cancer patients with multiple metastases will receive either usual care (like bone-strengthening drugs or…

This study compares two types of radiation therapy for men with early-stage prostate cancer. One method uses fewer, higher-dose treatments (SBRT), while the other uses more frequent, lower-dose sessions. The goal is to see which approach better controls the cancer while causing f…

This study tests whether the hormone therapy letrozole alone works as well as chemotherapy plus letrozole for people with stage II to IV low-grade serous ovarian, fallopian tube, or peritoneal cancer. Letrozole lowers estrogen, which can slow tumor growth. The trial aims to find …

This study compares proton beam therapy to standard photon radiation (IMRT) in 120 people with IDH-mutant grade II or III gliomas. The goal is to see which method better preserves memory and thinking skills after treatment. Both techniques aim to deliver radiation precisely to th…

This study looks at whether a dye called iohexol can help doctors more accurately calculate the right dose of the chemotherapy drug carboplatin for cancer patients. Researchers will compare different methods of estimating kidney function to see which one best predicts how the bod…