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Your own blood may be best during heart surgery: pilot study tests new approach

NCT ID NCT05889494

Disease control Sponsor: University of Alberta Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This pilot study tested a protocol for using a patient's own blood during heart surgery to see if it works as well as donated blood products. Sixty-four adult heart surgery patients at high risk for bleeding were randomly assigned to either donate their own blood during surgery or receive standard donated blood products. The main goal was to see if the protocol is practical and effective at reducing transfusions and complications.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Autologous whole blood management (patient's own blood donated and re-transfused during surgery)
What this could lead to
If this approach works, it could reduce the need for donated blood transfusions and lower complications after heart surgery.
What could go wrong
This is a small pilot study testing feasibility, not effectiveness. The results may not apply to all heart surgery patients, and the procedure may not reduce transfusions or complications as hoped.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

64 people

The number who actually took part.

Started

Mar 2025

Finished

Feb 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 85 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adult (≥18 yr) * Surgical patients at the Mazankowski Alberta Heart Institute * High risk for acquired coagulopathy Exclusion Criteria: * Left ventricular ejection fraction \<20% * Impaired renal function * Preoperative anemia (hematocrit \< 30%) * Abnormal coagulation studies or platelet function * Presence of hemoglobinopathy * Platelet count \< 120 10\*9/L * Non-heparin based CPB anticoagulation * Presence of carotid stenosis (≥70%) * Presence of bacteremia/endocarditis * Age \> 85 yr * Weight \< 55 kg * Hepatic failure/dysfunction * Pregnancy * Chronic lung disease on home O2 * Acute respiratory failure * Acute coronary syndromes * Emergency surgery

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Conditions

The condition(s) this trial relates to.

Postoperative Hemorrhage

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Postoperative anemia Postoperative blood loss Postoperative hemorrhage

Contacts and locations

Locations

  • University of Alberta

    Edmonton, Alberta, T6G2G3, Canada

More trials for these conditions

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