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Protein levels may predict anemia recovery after heart surgery

NCT ID NCT05384054

Knowledge-focused Sponsor: Yonsei University Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at 150 adults who had heart valve surgery to see if a protein called erythroferron is linked to changes in hemoglobin levels after surgery. Hemoglobin is important for carrying oxygen in the blood, and low levels (anemia) can slow recovery. The researchers measured erythroferron right after surgery and tracked hemoglobin over time. The goal was to understand how the body responds to blood loss and inflammation after surgery, which could help manage anemia better in the future.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

150 people

The number who actually took part.

Started

Jun 2022

Finished

Sep 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Patient older than 20 years and undergong elective valvular heart surgery.

Ages

20 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients older than 20 years * undergoing elective valvular heart surgery Exclusion Criteria: * Emergency operation * Co-operation with other surgeries * Patients with cardiogenic shock or ventricular-assist device (eg. ECMO, IABP) * Patients requiring mechanical ventilator care in preoperative period * Patient with severe chronic kidney disease (GFR(CKD-EPI) \<30ml/min/1.73m2) * Patients with preoperative infection status (Eg. Sepsis) * Patients with acute bleeding status * Hemoglobin concentration below 10g/dL * Disease directly affecting hematopoiesis (eg. Leukemia, myeloma, aplastic anemia) * Uncompensated liver cirrhosis, acute hepatitis, alcoholics * Patients who participated in other clinical studies that could affect prognosis * Patients who cannot understand the informed consent (eg. Foreigner)

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Postoperative anemia

Contacts and locations

Locations

  • Yonsei University Health System, Severance Hospital

    Seoul, South Korea

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