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Tailored surgery may save lives in aortic dissection

NCT ID NCT05912608

Disease control Sponsor: Centre Cardiologique du Nord Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only This study
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looks at two surgical approaches for repairing a tear in the aorta (the main artery from the heart) in 900 patients. One approach is less invasive (root-sparing), used for higher-risk patients, while the other is more extensive (root replacement and total arch repair), used for lower-risk patients. The goal is to see which strategy leads to fewer deaths and complications like stroke or heart attack.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
surgical procedure (root-sparing or root replacement with arch repair)
What this could lead to
If successful, this study could help surgeons choose the safest and most effective surgery for each patient with aortic dissection, potentially reducing deaths and complications.
What could go wrong
This is an observational study, not a randomized trial, so results may be influenced by patient selection. The surgeries themselves carry serious risks like stroke, heart attack, and spinal cord injury.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 900 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jan 2024

Expected to finish

Dec 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 90 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * TAAD or intramural hematoma involving the ascending aorta * Patients aged \> 18 years * Symptoms started within 7 days from surgery * Primary surgical repair of acute TAAD * Any other major cardiac surgical procedure concomitant with surgery for TAAD. Exclusion Criteria: * Patients aged \< 18 years * Onset of symptoms \> 7 days from surgery * Prior procedure for TAAD * Concomitant endocarditis; * TAAD secondary to blunt or penetrating chest trauma.

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Conditions

The condition(s) this trial relates to.

Aortic Dissection

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Aortic dissection

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    The full official record for this study. This one lists no contact details, but it is the first place any would appear.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Francesco Nappi

    Saint-Denis, 93200, France

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