Could this mouthrinse be the key to beating gum disease?
NCT ID NCT07414173
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This 6-month study tests whether a special antimicrobial mouthrinse can reduce plaque buildup and improve gum health in adults with gingivitis. Participants will brush and rinse twice daily and visit the clinic every 3 months. The goal is to see if the rinse helps control gum inflammation and plaque better than a standard fluoride rinse.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- antimicrobial mouthrinse with fluoride, amine, and zinc lactate
- What this could lead to
- If it works, this could provide a simple, effective way to manage gum disease and plaque at home.
- What could go wrong
- This is a small, early-phase study testing a mouthrinse, so results may not apply to everyone. The improvement may be modest and not a cure for gum disease.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Phase 4
Runs after approval, following long-term safety and how well the treatment works in everyday use.
- Participants
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About 90 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Jan 2026
- Expected to finish
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Nov 2026
An estimate. End dates often move.
- Lead sponsor
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A company
The lead sponsor is a pharmaceutical, biotech, or medical-device company.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 70 years
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: 1. Male and female subjects aged 18-70 years, inclusive. 2. Availability for the 6-month duration of the clinical research study. 3. Good general health based on the opinion of the study investigator. 4. Signed Informed Consent Form. 5. Minimum of 20 natural teeth (excluding third molars). 6. Initial gingivitis index of at least 1.5 as determined by the use of the Loe and Silness Gingival Index. 7. Initial plaque index of at least 1.5 as determined by the use of the Quigley and Hein Plaque Index (Turesky Modification). Exclusion Criteria: 1. Be under orthodontic treatment. 2. Presence of partial removable dentures. 3. Tumor(s) of the soft or hard tissues of the oral cavity. 4. Participants with current moderate or severe periodontitis (periodontitis screening index \[PSI\] \>2 in more than 2 sextants or PSI \>3), and/or purulent exudate, tooth mobility, and/or extensive loss of periodontal attachment or alveolar bone. 5. Five or more carious lesions requiring immediate restorative treatment. 6. Antibiotic use any time during the one-month period prior to entry into the study. 7. Participation in any other clinical study or test panel within the one month prior to entry into the study. 8. Dental prophylaxis during the past two weeks prior to baseline examinations. 9. History of allergies to oral care/personal care consumer products or their ingredients. 10. On any prescription medicines that might interfere with the study outcome based on the examiner/PI opinion. 11. An existing medical condition that prohibits eating and/or drinking for periods up to 4 hours. 12. History of alcohol and/or drug abuse. 13. Self-reported pregnancy and/or lactating subjects. 14. Subjects with other oral diseases (including gingival hyperplasia, diseases of the oral mucosa), or any condition that the dental examiner considers exclusionary from the study. 15. Smokers or/and users of tobacco products. 16. Enrolled in an undergraduate, postgraduate, or academic dentistry program
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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SGS proderm GmbH
RECRUITINGSchenefeld, 22869, Germany
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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- Can a special toothpaste tame gum disease?
- Can a special toothbrush clean better around braces?
- Could a toothbrush and mouthwash cut pneumonia in the elderly?