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New study questions rush to antibiotics for ventilator lung infections

NCT ID NCT06743529

Disease control Sponsor: Nantes University Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Sep 02, 2026 · Updated 3 times

Summary

This study compares two approaches for treating suspected ventilator-associated pneumonia (VAP) in ICU patients who are not severely ill. One group gets antibiotics immediately, while the other waits for lab confirmation. The goal is to see if waiting reduces unnecessary antibiotic use without increasing deaths or time on a ventilator. About 686 adults on ventilators for more than 48 hours will take part.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
antibiotics
What this could lead to
If it works, this could show that waiting for lab confirmation before starting antibiotics is safe for non-severe VAP, reducing unnecessary antibiotic use and fighting resistance.
What could go wrong
This is an early-stage trial with 686 participants. The conservative strategy might delay treatment for some infected patients, potentially worsening outcomes. Results may not apply to severe cases.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 686 people

The number the study aims to enrol. It can still change while the study runs.

Started

Nov 2025

Expected to finish

Feb 2029

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Invasive mechanical ventilation for longer than 48 hours * Respiratory sample collection taken less than two hours ago (at physician discretion, according to local protocol) for a first episode of suspected ventilator-associated pneumonia (meeting the following prespecified criteria) : * new or changing chest X-ray infiltrates * plus at least two of the following: * body temperature ≥38°C or ≤35.5°C, * blood leukocyte count \>12 000/µL or \<4000/µL, * purulent tracheobronchial aspirate. * Age ≥18 years * Informed consent from the patient or next of kin to participation in the trial, or emergency procedure if no next of kin is available * Patients affiliated to a social security system Non-inclusion Criteria: * Criteria for severe ventilator-associated pneumonia defined as: * Vasopressor therapy for onset of septic shock around the time of ventilator-associated pneumonia suspicion * Onset or severe worsening of hypoxemia (PaO2/FiO2\<150 with 60% FiO2 and 10 mm H2O peak expiratory pressure, or patient on veno-venous extracorporeal membrane oxygenation) * Immunosuppression defined as : * leukocytes \<1G/L or neutrophils \<0,5 G/L * within the last 3 months * hematopoietic stem-cell transplant or organ transplant with chronic immunosuppressant therapy * HIV infection with CD4\<50/mm3 * chronic corticosteroid use (\>0.5 mg/kg day for at least one month within the last three months). * Patient already on Antibiotic Therapy of predicted duration ≥4 weeks (endocarditis, spondylodiscitis, abscess...) * Previous ventilator-associated pneumonia suspicion with sampling and/or Antibiotic Therapy for suspected ventilator-associated pneumonia * Previous inclusion in the trial * Patient included in an interventional study on ventilator-associated pneumonia management with the same primary endpoint. * Pregnancy, recent delivery, or breastfeeding * Correctional facility inmate, adult under guardianship * Patient under legal protection * Life expectancy less than 48 h and/or decision not to treat potential pneumonia acquired under mechanical ventilation in the context of limiting/discontinuing treatment. * Organ donor reanimation

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Conditions

The condition(s) this trial relates to.

Pneumonia, Ventilator-Associated

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Ventilator-associated pneumonia (VAP)

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    42 sites in 2 countries. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • APHP - Hôpital Cochin

    RECRUITING

    Paris, 75014, France

  • APHP - Hôpital Raymond Poincaré

    RECRUITING

    Garches, 92380, France

  • APHP - Hôpital Tenon

    RECRUITING

    Paris, 75020, France

  • CH Angoulème

    RECRUITING

    Angoulème, France, 16000, France

  • CH Argenteuil

    RECRUITING

    Argenteuil, France, 95100, France

  • CH Avignon

    RECRUITING

    Avignon, 84000, France

  • CH Bretagne Atlantique

    RECRUITING

    Vannes, 56017, France

  • CH Cholet

    RECRUITING

    Cholet, 49325, France

  • CH Dax

    RECRUITING

    Dax, 40107, France

  • CH Emile Roux

    RECRUITING

    Le Puy-en-Velay, 43000, France

  • CH Le Mans

    RECRUITING

    Le Mans, 72000, France

  • CH Public du Cotentin

    RECRUITING

    Cherbourg, 50102, France

  • CH Simone Veil

    RECRUITING

    Cannes, 06414, France

  • CH Versailles

    RECRUITING

    Le Chesnay, 78157, France

  • CH d'Arles

    RECRUITING

    Arles, 13637, France

  • CH de Melun

    RECRUITING

    Melun, 77000, France

  • CH de Mont de Marsan

    RECRUITING

    Mont-de-Marsan, 40000, France

  • CH de Pau

    RECRUITING

    Pau, 64000, France

  • CH de Saint-Malo

    RECRUITING

    St-Malo, 35403, France

  • CH de Saint-Nazaire

    RECRUITING

    Saint-Nazaire, 44600, France

  • CH de Valenciennes

    RECRUITING

    Valenciennes, 59300, France

  • CHD Vendée

    RECRUITING

    La Roche-sur-Yon, 85025, France

  • CHR d'Orléans

    RECRUITING

    Orléans, 45100, France

  • CHRU De Tours

    RECRUITING

    Tours, 37044, France

  • CHRU Lille

    RECRUITING

    Lille, 59037, France

  • CHRU de Strasbourg - Nouvel Hôpital Civil

    RECRUITING

    Strasbourg, 67091, France

  • CHRU de Strasbourg -Hôpital de Hautepierre

    RECRUITING

    Strasbourg, 67098, France

  • CHU Angers

    RECRUITING

    Angers, France, 49000, France

  • CHU Clermont-Ferrand

    RECRUITING

    Clermont-Ferrand, 63003, France

  • CHU Dijon

    RECRUITING

    Dijon, 21033, France

  • CHU La Guadeloupe

    RECRUITING

    Pointe-à-Pitre, 97159, Guadeloupe

  • CHU Nantes

    RECRUITING

    Nantes, France, 44000, France

  • CHU Nice - Hôpital de l'Archet

    RECRUITING

    Nice, 06200, France

  • CHU Nice -Hôpital Pasteur

    RECRUITING

    Nice, 06100, France

  • CHU Rennes

    RECRUITING

    Rennes, 35033, France

  • CHU de Bordeaux

    RECRUITING

    Bordeaux, 33076, France

  • CHU de Bordeaux

    RECRUITING

    Bordeaux, France

  • CHU de Lyon - Hôpital Edouard Herriot

    RECRUITING

    Lyon, 69437, France

  • GHB Sud- Hôpital de Lorient

    RECRUITING

    Lorient, 56100, France

  • Hôpital Européen Marseille

    RECRUITING

    Marseille, France

  • Hôpital Foch

    RECRUITING

    Suresnes, 92150, France

  • Hôpital Nord Franche Comté

    RECRUITING

    Belfort, 90000, France

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