Can a cheap pill fix stiff arteries in insulin resistance?
NCT ID NCT03837626
First seen Sep 30, 2025 · Last updated Jun 23, 2026 · Updated 27 times
Summary
This study tested whether amiloride, a drug that blocks a salt-regulating protein called ENaC, can improve artery flexibility in overweight or obese adults with insulin resistance. 137 participants took either amiloride or a placebo daily for 6 months. The main goal was to measure arterial stiffness using a gold-standard test. The results could help develop new ways to protect heart health in people with metabolic syndrome.
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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University of Missouri Hospital and Clinics
Columbia, Missouri, 65201, United States
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Amiloride (a pill that blocks ENaC, a protein involved in salt balance)
What this could lead to
If it works, this could point toward a treatment to reduce arterial stiffness and improve heart health in people with insulin resistance.
What could go wrong
This is a small, completed Phase 2/3 trial. Results may not apply to everyone, and amiloride can cause side effects like electrolyte imbalances. The benefit may be modest.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.