Could a cheap pill fix stiff arteries in insulin resistance?
NCT ID NCT03837626
First seen Sep 30, 2025 · Last updated Jun 23, 2026 · Updated 28 times
Summary
This study tested whether amiloride, a drug that blocks sodium channels, can improve artery stiffness and blood vessel function in people who are overweight and insulin resistant. 137 men and women (pre- and postmenopausal) took either amiloride or a placebo daily for 6 months. The main goal was to see if the drug could reduce a key measure of arterial stiffness, which is a risk factor for heart disease.
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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University of Missouri Hospital and Clinics
Columbia, Missouri, 65201, United States
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Amiloride (a pill that blocks sodium channels in cells)
What this could lead to
If successful, this could point toward a simple, low-cost way to reduce artery stiffness and heart disease risk in people with insulin resistance.
What could go wrong
This is a small, completed trial. The drug may not show clear benefits, or results may not apply to all groups. Amiloride can affect kidney function and electrolyte balance.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.