New study tests which technique best stops colon polyps from coming back
NCT ID NCT06476145
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 2 times
Summary
This study compares two methods used during colonoscopy to remove large, flat colon polyps: marking the edges before removal or using heat to treat the edges after removal. The goal is to see which method better prevents polyps from growing back. About 342 adults with polyps 20 mm or larger will take part.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- endoscopic mucosal resection with margin marking or snare tip soft coagulation
- What this could lead to
- If one technique works better, it could reduce the need for repeat colonoscopies and lower the risk of colon cancer from recurring polyps.
- What could go wrong
- This is an early-stage comparison of two existing techniques, not a new drug or cure. The difference in recurrence rates may be small, and results may not apply to all polyp types.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Participants
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About 342 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Dec 2023
- Expected to finish
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Jan 2027
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
Primary Care Clinic
- Ages
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18 years and older
- Sex
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Anyone
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: 1. Age 18 years or older 2. Ability to provide informed consent 3. Patient scheduled to undergo colonoscopy for the evaluation and removal of colon polyps 4. Non-pedunculated polyps ≥ 20 mm size Exclusion Criteria: 1. Pedunculated polyps 2. Inflammatory bowel disease 3. Inability to provide informed consent 4. Lesions \< 20 mm in size (largest dimension) 5. Lesion involves the lips of the ileocecal valve, is located at the appendiceal orifice and/or is fully circumferential. 6. Any standard contraindication, including pregnancy, to anesthesia and/or colonoscopy
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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AdventHealth
RECRUITINGOrlando, Florida, 32804, United States
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