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Can we predict a better outcome after ACL revision surgery?

NCT ID NCT00625885

Knowledge-focused Sponsor: Vanderbilt University Medical Center Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 24, 2026 · Last updated Aug 25, 2026 · Updated 1 time

Summary

This study follows people who need a second surgery to repair a torn anterior cruciate ligament (ACL) in the knee. It looks at whether factors like the cause of the first failure, the type of graft used, and surgical technique can influence quality of life, physical activity, and the chance of developing early arthritis. By tracking outcomes over time, the researchers hope to identify what can be changed to improve long-term knee health.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this research could identify factors that improve recovery and reduce the risk of re-injury or early arthritis after a second ACL surgery.
What could go wrong
This is an observational study, so it cannot prove cause and effect. Results may not apply to all patients, and the long follow-up needed to see osteoarthritis may limit conclusions.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

1,234 people

The number who actually took part.

Started

Mar 2006

Expected to finish

Aug 2030

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

All ACL-deficient candidates scheduled for a revision ACL reconstruction at one of the participating MARS sites.

Ages

12 to 65 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * All ACL-deficient candidates presenting to the clinic, between the ages of 12† and 65, scheduled to have a revision ACL reconstruction by a participating (MARS Study) surgeon. * All participants must have undergone a primary ACL reconstruction in the past and are currently identified as having experienced failure of their primary ACL reconstruction, as defined by either MRI, knee laxity (KT \> 5mm), a positive pivot shift or Lachman's, functional instability, and/or by arthroscopic confirmation. * All ACL-deficient patients seeking a revision ACL reconstruction that have either partial (Grade I or II) and/or complete (Grade III) simultaneous ligamentous injuries to the collateral ligaments (MCL or LCL) and/or the posterior cruciate ligament (PCL) will also be included. * Non-operative treatment of patients with ACLR failure are also eligible to participate. * The following graft types will be the only ones accepted for inclusion: * any autograft * Fresh-frozen allografts from a single donor source (Musculoskeletal Transplant Foundation (MTF); Edison, NJ). These grafts should consist of either: * bone-patellar tendon-bone * tibialis anterior/posterior * achilles tendon Exclusion Criteria: * Patients presenting with prior infection, arthrofibrosis, or regional pain syndrome. * Subjects will be excluded if their allograft source does not come from MTF. * Patients unwilling or unable to complete their repeat questionnaire two years after their initial visit.

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Conditions

The condition(s) this trial relates to.

Anterior Cruciate Ligament Injuries Knee Injuries

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Rupture of anterior cruciate ligament

Contacts and locations

Locations

  • Beth Israel Deaconess Medical Center

    Boston, Massachusetts, 02215, United States

  • Booth, Bartolozzi, Balderston Orthopaedics

    Philadelphia, Pennsylvania, 19107, United States

  • Bridger Orthopaedic and Sports Medicine

    Bozeman, Montana, 59715, United States

  • Cheaspeake Orthopaedics and Sports Medicine Center

    Glen Burnie, Maryland, 21061, United States

  • Cleveland Clinic

    Cleveland, Ohio, 44195, United States

  • Commonwealth Orthopaedics and Rehabilitation

    Vienna, Virginia, 22181, United States

  • Connecticut Children's Medical Center

    Farmington, Connecticut, 06032, United States

  • Duke University

    Durham, North Carolina, 27710, United States

  • Fowler Kennedy Sports Medicine Clinic/Univ. of Western Ontario

    London, Ontario, Canada

  • Hospital for Special Surgery

    New York, New York, 10021, United States

  • Inland Orthopaedics/Washington State University

    Pullman, Washington, 99163, United States

  • Intermountain Orthopaedics

    Boise, Idaho, 83703, United States

  • Keller Army Community Hospital - USMA

    West Point, New York, 10996, United States

  • Manhattan Orthopaedics, P.C.

    New York, New York, 10021, United States

  • Mayo Clinic

    Rochester, Minnesota, 55905, United States

  • Methodist Sports Medicine Center

    Indianapolis, Indiana, 46280, United States

  • NYU School of Medicine

    New York, New York, 10016, United States

  • National Sports Medicine Institute

    Lansdowne Town Center, Virginia, 20176, United States

  • New Hamphsire Knee Center

    Holderness, New Hampshire, 03217, United States

  • Orthopaedic Associates of Aspen and Glenwood

    Aspen, Colorado, 81611, United States

  • Orthopaedic Institute

    Sioux Falls, South Dakota, 57115, United States

  • Orthopaedic and Fracture Clinic

    Portland, Oregon, 97225, United States

  • Perry Orthopaedics and Sports Med (Carolinas Healthcare System)

    Charlotte, North Carolina, 28211, United States

  • Princeton Orthopaedic Associates

    Princeton, New Jersey, 08540, United States

  • Regions Hospital (Health Partners Research Foundation)

    Saint Paul, Minnesota, 55101, United States

  • Robert Wood Johnson Medical School

    New Brunswick, New Jersey, 08901, United States

  • Royal Columbian Hospital (FraserHealth)

    New Westminster, British Columbia, V3L3W7, Canada

  • Rush University Medical Center

    Chicago, Illinois, 60612, United States

  • San Antonio Orthopaedic Group

    San Antonio, Texas, 78216, United States

  • Scripps Memorial Hospital (OrthoCal Healthcare)

    La Jolla, California, 92123, United States

  • Slocum Research and Education Foundation

    Eugene, Oregon, 97401, United States

  • Southeastern Orthopaedics / Knoxville Orthopaedic Clinic

    Knoxville, Tennessee, 37909, United States

  • The Ohio State University

    Columbus, Ohio, 43221, United States

  • The Rothman Institute / Thomas Jefferson University

    Philadelphia, Pennsylvania, 19085, United States

  • Town Center Orthopaedic Associates

    Reston, Virginia, 20190, United States

  • UHZ Sports Medicine Institute

    Coral Gables, Florida, 33146, United States

  • University of Buffalo

    Buffalo, New York, 14214, United States

  • University of California - Los Angeles (UCLA)

    Los Angeles, California, 90095, United States

  • University of California - San Francisco

    San Francisco, California, 94143, United States

  • University of Colorado

    Boulder, Colorado, 80304, United States

  • University of Connecticut Health Center

    Farmington, Connecticut, 06034, United States

  • University of Iowa

    Iowa City, Iowa, 52242, United States

  • University of Michigan

    Ann Arbor, Michigan, 48106, United States

  • University of North Carolina Medical Center

    Chapel Hill, North Carolina, 27599, United States

  • University of Pennsylvania

    Philadelphia, Pennsylvania, 19104, United States

  • University of Vermont College of Medicine

    Burlington, Vermont, 05405, United States

  • Vanderbilt University

    Nashville, Tennessee, 37232, United States

  • W.B. Carroll Memorial Clinic

    Dallas, Texas, 75204, United States

  • Washington University at St. Louis

    St Louis, Missouri, 63141, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.