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Massive study tracks 3,000+ ACL patients to predict knee outcomes

NCT ID NCT00463099

Knowledge-focused Sponsor: Vanderbilt University Medical Center Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Aug 25, 2026 · Updated 2 times

Summary

This study follows over 3,200 people who had surgery for a torn ACL. Researchers want to learn which factors affect knee function, arthritis, and the chance of re-injury. Participants complete surveys and have X-rays over time to track their recovery.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

3,294 people

The number who actually took part.

Start date

Jan 2002

Expected to finish

Dec 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

All eligible ACL-deficient candidates scheduled for a unilateral ACL reconstruction at one of the participating MOON sites.

Ages

10 to 80 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: \- All ACL-deficient candidates scheduled for a unilateral ACL reconstruction at one of the participating MOON sites. Exclusion Criteria: * Persons undergoing a simultaneous bilateral ACL reconstruction * Patients less than 10 years old and older than 80 years old * Patients unwilling or unable to complete their follow-up questionnaire

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Conditions

The condition(s) this trial relates to.

Anterior Cruciate Ligament Injuries Knee Injuries

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Rupture of anterior cruciate ligament

Contacts and locations

Locations

  • Cleveland Clinic

    Cleveland, Ohio, 44195, United States

  • Duke University

    Durham, North Carolina, 27710, United States

  • Hospital for Special Surgery

    New York, New York, 10021, United States

  • The Ohio State University

    Columbus, Ohio, 43221, United States

  • University of Colorado

    Boulder, Colorado, 80304, United States

  • University of Iowa

    Iowa City, Iowa, 52242, United States

  • Vanderbilt University Medical Center

    Nashville, Tennessee, 37232, United States

  • Washington University at St. Louis

    St Louis, Missouri, 63141, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.