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Can a gentle brain zapping boost fading memory?

NCT ID NCT07752316

Symptom relief Sponsor: The National Brain Mapping Laboratory (NBML) Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 07, 2026 · Last updated Aug 07, 2026

Summary

This trial tests whether a non-invasive technique called transcranial alternating current stimulation (tACS) can improve memory and thinking in older women with mild cognitive impairment (MCI). MCI involves a decline in cognitive abilities beyond normal aging, raising dementia risk, and effective treatments are limited. The study randomly assigns 30 women aged 60-75 to receive either active 80 Hz tACS or a sham (placebo) stimulation, with neither participants nor the person delivering the stimulation knowing which they receive. Cognitive tests before and after the sessions will compare changes in overall cognitive status, planning, working memory, and reaction speed between the two groups.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
transcranial alternating current stimulation (tACS) at 80 Hz
What this could lead to
If effective, this non-invasive brain stimulation could offer a new way to ease memory and thinking problems in people with mild cognitive impairment, potentially slowing the path to dementia.
What could go wrong
This is a small, early-stage trial with only 30 participants, so results may not apply broadly. The stimulation may not improve cognition, and side effects like tingling or itching at the scalp are possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

30 people

The number who actually took part.

Started

Mar 2024

Finished

Oct 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

60 to 75 years

Sex

Female participants only

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Female, aged 60 to 75 years * Diagnosis of mild cognitive impairment (MCI) established by a psychiatrist and documented in the patient's medical record * Montreal Cognitive Assessment (MoCA) score between 16 and 22 * Written informed consent to participate in the study * No history of Parkinson's disease, stroke, epilepsy, schizophrenia, or congenital olfactory and gustatory disorders Exclusion Criteria: * Inability to tolerate the adverse effects of the stimulation * Unwillingness to continue the sessions * Absence from more than three intervention sessions

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Conditions

The condition(s) this trial relates to.

Cognitive Dysfunction

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Mild cognitive impairment (MCI)

Contacts and locations

Locations

  • Department of Psychology, University of Mohaghegh Ardabili

    Ardabil, Iran

More trials for these conditions

Other studies related to the condition(s) this trial covers.