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Radioactive drug targets tough lung cancers in early trial

NCT ID NCT06736418

First seen Feb 26, 2026 · Last updated Jun 18, 2026 · Updated 16 times

Summary

This early-phase study tests a new radioactive drug, 225Ac-ABD147, in people with small cell lung cancer or large cell neuroendocrine lung cancer that has spread and was previously treated with platinum chemotherapy. The main goals are to check safety, find the best dose, and see if the drug can shrink tumors. About 17 participants will receive the drug, and some will also get an imaging agent to see where the drug goes in the body.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • Dana-Farber Cancer Institute

    Boston, Massachusetts, 02215, United States

  • Florida Cancer Specialists - Sarasota

    Sarasota, Florida, 34232, United States

  • Hoag Memorial Hospital Presbyterian

    Newport Beach, California, 92663, United States

  • Huntsman Cancer Institute

    Salt Lake City, Utah, 84112, United States

  • MD Anderson

    Houston, Texas, 77030, United States

  • Mayo Clinic - Jacksonville

    Jacksonville, Florida, 32224, United States

  • Mayo Clinic - Rochester

    Rochester, Minnesota, 55905, United States

  • Memorial Sloan Kettering Cancer Center

    New York, New York, 10065, United States

  • Sylvester Comprehensive Cancer Center, Univ of Miami

    Miami, Florida, 33136, United States

  • United Theranostics

    Glen Burnie, Maryland, 21061, United States

  • University of California, Los Angeles

    Santa Monica, California, 90404, United States

  • University of California, San Francisco

    San Francisco, California, 94143, United States

Conditions

The condition(s) this trial relates to.

lung neoplasm pulmonary large cell neuroendocrine carcinoma small cell lung carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.